Browsing by Author "Gebregziabiher, Abraham"

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    Valuing health-state: an eq-5d-5l value set for Ethiopians
    (Addis Ababa Universty, 2018-11) Gebregziabiher, Abraham; Gedif, Teferi (BPharm,MSc, PhD)
    Background: There is a growing interest in health technology assessment and economic evaluations in developing countries using measures such as EQ-5D-5L (European quality 5 dimension- 5 level). However, the main challenge is lack of local population value sets which are recommended in most countries as they reflect local preferences. Objective: To obtain social preference and establish an EQ-5D-5L value set from the Ethiopian general population. Methods: A sample reflecting urban, and rural population (n= 1,050) was recruited using stratified multi-stage quota sampling technique. Face-to-face, computer-assisted interviews using the EuroQol Portable Valuation Technology (EQ-PVT) software of composite time trade-off(c-TTO) and discrete choice experiments (DCE) were undertaken to elicit preference score. The feasibility of EQ-PVT was pilot tested in a sample of the population (n=110). A hybrid regression model combining c-TTO and DCE data was used to estimate the final value set. Results: The pilot study revealed that the feasibility of EQ-PVT protocol was good and there were no special concerns with undertaking TTO task. The predicted value for the EQ-5D-5L ranged from-0.7186 to 1. The coefficients generated from a hybrid model were logically consistent. Anxiety/depression showed the most impact to utility decrement of 0.4578, and self-care influenced the least 0.2224. The maximum predicted value beyond full health was 0.9741 for the ‘11112’ (health state of slight problem in anxiety/depression dimension). Conclusions: This study established Ethiopian value set for EQ-5D-5L on the basis of c-TTO and DCE. It is expected to facilitate health economic evaluations, health-related quality of life research and to inform decision making in Ethiopia.