Browsing by Author "Gebregiorgis Mahlet"

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    Assessment of Utilization, Practice, Indication and Complications of Blood and Blood Component Therapy at Internal Medicine Wards Tikur Anbessa Specialized Hospital.
    (Addis Abeba University, 2019-11) Gebregiorgis Mahlet; Gebremedhin Amha
    Background: Despite the increased use of blood and blood component transfusion there seems to be an obvious lack in the knowledge and practice of the process. There is also a lack of institution wide guideline on the practice and adequate training given to physicians. This is a special concern because even though blood and blood component transfusion is a life saving process it carries its own risks. Objective: To evaluate the utilization, practice, indications, complications of blood and blood component therapy in medical patients admitted to Tikur Anbessa hospital. Methodology: Institutional based prospective quantitative descriptive study will be conducted to assess utilization, indications, complications of blood and blood component transfusion. Data will be collected using pre prepared check list and will be analyzed using Statistical Package for Social Sciences, version 20. Results: During the study period there were a total of 329 units of blood and blood component issued to the medical wards with 148 episodes of transfusion. Male patients accounted for % of patients and females accounted for -%. The most common age group transfused was (n = %). The most common indication for transfusion is (n = %). He most common primary diagnosis is ( n %). The most commonly used blood component is (n = %). Vital sign was recorded only in (n = 8, 5.4%) prior to transfusion, (n = 5, 3.4%) during transfusion and (n = 10, 6.8%) post transfusion. Conclusion: This study provides information about the trend of utilization, indication and practice of blood and blood component therapy in medical wards of black lion hospital. The data obtained will help to guide improve transfusion practice, and planning for future needs in blood and component therapy in the future
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    Clinical Characteristics, Treatment outcome and Determinants of Outcome in Patients with Multiple Myeloma Treated at TASH from January 2017 to December 2021:A five years Retrospective study
    (Addis Ababa University, 2023-03) Gebregiorgis Mahlet; Tadess Fissehatsion
    Background፡Multiple myeloma is a malignant proliferation of plasma cells in the bone marrow, withrelatively high prevalence in African populations. Reports from Africa are few and involve small cohorts, but suggest significant epidemiological and clinical differences from Caucasian patients.The outcome of myeloma has significantly improved due to use of chemotherapeutic agents including immunomodulatory agents and proteasome inhibitors. Methods፡A retrospective Cross-sectional study design was used to define the clinical characteristics,outcome and determinants of outcome of multiple myeloma patients treated at TASH from January 1,2017 to December 30,2021. Result፡A total of 85 patients were included in the study. The median age at diagnosis was 53 years, male patients accounted for 64.7 % of the patients. The most common presenting symptoms were bone pain 85.9 % and symptoms of anemia 48.2 %. 41.2 % of patients had hg < 10 g/dl at presentation while 76.5 % had lytic lesions on imaging. In addition, 85.1 % had detectable paraprotein on SPEP. At the end of induction therapy 55.2 % of patients had undetectable paraprotein on SPEP.The median PFS for this cohort was 24 months. Conclusion፡Most patients with multiple myeloma in this cohort were diagnosed at a relatively young age,presented with late stage disease and bone pain, and had a shorter PFS. Factors associated with worse survival were late Durie-Salmon stage disease, high calcium, and presence of pathologic fracture.