Browsing by Author "G/Micael, G/Meskel"

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    Phytochemical Investigation on the Leaves of Achyranthes Aspera
    (Addis Ababa University, 2013-10-10) G/Micael, G/Meskel; Fiseha, Asebir (PhD)
    Achyranthes aspera is a well known medicinal plant in the family Amaranthaceae. The plant is locally known as “Telenge”. It is traditionally used in asthma and cough. The root of Achyranthes aspera is used for anti snake bite by giving the ground root with water until the patient vomits and regains consciousness while the crushed leaves are used to cure strained back. Phytochemical investigation on the leaves of this plant resulted in the isolation of two compounds (AA-1and AA-2). Compound AA-1 is a sesquiterpene while compound AA-2 is an insect molting ecdysteroid hormone namely: 1.) 4,4a,7,8-tetrahydro-4-hydroxy-4a,7,8-trimethyl-8-(tetrahydro-3,4,5-trihydroxy-6- (hydroxymethyl)-2H-pyran-2-yloxy)naphthalen-2(3H)-one 2.) 20-hydroxyecdysone. Structural elucidations of those compounds are based on IR, UV, 1D NMR (1H, 13C &DEPT) and 2D NMR (COSY, HMQC &HMBC) spectroscopic data obtained and in comparison with similar compounds isolated from the plant. To the best of my knowledge, there is no report for the isolation of the first compound (AA-1) from this plant and other families and species.