Browsing by Author "Ebrahim, Fatuma"

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    Survival Analysis of Hiv/Aids Patients on Anti-Retro Viral Therapy and Progression of Hiv/Aids Disease: the Case of Alert Hospital in Addis Ababa, Ethiopia
    (Addis Ababa University, 2020-06-06) Ebrahim, Fatuma; Tesfaw, Dejen (PhD)
    HIV is a virus that causes AIDS which attacks and destroys certain types of white blood cells that are essential to body's immune system, the biological ability of the human body to _ght infections. The main objective of the study was to identify the factors that a_ect the survival time of HIV/AIDS patients and progression of HIV/AIDS disease of an individual patient under ART follow-up. A retrospective cohort study was conducted on 729 HIV/AIDS pa- tients who enrolled anti-retro viral therapy from September 2013 to August 2017 at ALERT hospital in Addis Ababa, Ethiopia. Kaplan-Meier plots and Log-Rank test were used to compare the survival experience of di_erent cat- egories and semi-parametric survival model and AFT models were employed to identify survival time of the patients. Semi-markov model also employed to identify the progression of the diseases. From 729 patients, 86(11.8%) died in the follow-up period. Log-logistic AFT model is better _t the data then other AFT models. The result of this model shows that the survival time of HIV patients under HAART signi_cantly a_ected by functional sta- tus, clinical stage, adherence level, CD4 count, weight and BMI. The result of homogeneous semi-Markov model suggest that at the time increase, the probability to remain in the same state is decreasing while the probability of the patient transiting to a next worse state is increasing.