Browsing by Author "Dandena Yonas"

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    Demographic, Clinical, Pathologic and Treatment Pattern of Soft Tissue Sarcoma at Tikur Anbessa Specialized Hospital,Ethiopia.
    (Addis Ababa University, 2022-02) Abeje Melsew; Dandena Yonas
    Abstract : Soft tissue sarcomas are an uncommon group of neoplasm that could be fatal, especially in the metastatic setting. Late presentation, Missed Diagnosis and inadequate treatment may worsen clinical outcomes. There is lack of evidence on the demographic, pathological, Clinical and treatment pattern of soft tissue sarcoma in developing countries like Ethiopia Thus, this study is aimed to assess the demographic, pathological, Clinical and treatment patterns of soft tissue sarcoma in a single tertiary health institution in Ethiopia. Objective: The aim of this study is to assess demographic, pathologic, clinical and treatment pattern of soft tissue sarcoma at Tikur Anbesa Specialized hospital at four years duration. Methods :This is a retrospective cross-sectional study that asses demographic, clinical,pathologic and treatment pattern of soft tissue sarcoma at the TASH between august 2017 and August 2021 G.C. This period was selected because most patient data before this are not available according to my pilot study. Result: A total of 320 patients were registered from August 2017 to August 2021 and 190 patients card were available for this study and 80 of patients were excluded according to exclusion criteria and 50 of patients’ card were lost. The median age was 32 years of age and Male sex was commonly affected accounting 61.6% and female sex accounts 38.4%. The commonest sites were extremities accounting for 48.9 % of cases. The Commonest presenting symptoms were mass and pain accounting for 93.2% and 77.9% of cases respectively. The commonest histology subtypes were, un differentiated sarcoma, rhabdomyosarcoma and synovial sarcoma accounting 50%, 15.8% and 6.3 % cases respectively. The grade of the lesions was described in 67.3 % of patients. Of those lesions whose grade was described 56.8 % were high grade lesions. From all cases 58.3% of the patients underwent surgery as a primary treatment modality. Only 50.5% of cases were started treatment with curative intent and 49.5% of the case started their treatment with palliative intent. Conclusion: The pattern of soft tissue sarcoma in this cross sectional study has shown different distribution in terms of demography, clinical presentation, treatment and pathological subtypes when compared to other studies. Advanced stage of initial clinical presentation and substandard work up according to standard text books and therapy makes it unique from cases reported from other parts of the world
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    Dosimetrice Valuation of Palliative Hypo Fractionated Radiotherapy and its Effect on Clinical Outcome Inpatients with Vertebral Bone Metastasis Treated at Tikur Anbessa Specialized Hospital,Oncology Center, Addis Ababa,Ethiopia:An Institution -Based Retrospective Cross-Sectional Study.
    (Addis Ababa University, 2023-12) Gulilat Addis; Dandena Yonas; Belay Eskadmas
    The purpose of this tudywastoevaluatedosimetri cparametersofthree-di conformalradiotherapy(3D-CRT)andanal yzeitseffectoncl controlandtoxi city.Assessmentofthetreatmentpl mensional inicaloutcomesincl udingpain ansinthestudywascarriedoutbasedon reporteddosimetri cparameters,whereaspatientreportedpai nscoreandtoxicitywereusedfor assessingresponse. Methods:Aninstituti on-basedretrospecti s.Stati vecrosssectionalstudywasconductedfromJune Sept2023. ThedatawascollectedusingKobotoolboxandwasexportedtoSPSSversion26 foranalysi sticaltestsandanal ysiswasconducted.Variabl signifi cancep-value110%,thelargestbeing117%.Acutetoxicity wasseenin36(37.1%)ofpatientsfromthese23.4%wassevere.Theconformityindexwas foundtobeb/n1-2in97%ofthecases.Incontrary,homogeneityindexwasdifferentfromzero in100%ofthecases.OfpatientswhosemeandosewasmeasuredlungDmeanwas>13GYin 2(4.4%)pati entswhilekidneyDmeanwas>18GY(EQD2)in1(1.5%).Thereasonforpoor coverage,hi ghDmaxdoseandhighmeandoseforOARsmaybethewrongassumptionof consideri ngallpall iati vepatientsasshorttermsurvi vors,andadvancedpresentati diffusevertebralmetastasi sresulti ngdiffi Conclusion:Adeviati cultyonplanoptimizati onwith on. onfromrecommendedvaluewasseeninD95%,Dmax,DmeanandHI.This suggestsasthereshouldbemoreefforttooptimizepl ansandstrictl yevaluatetheDVH.Lack ofsignifi cancerelati ononmultivariateanal ysismaybeduetosamplesizeandthosecasesthat hadtoxicitymighthavemissedduetoearlydeat
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    Patterns of Gastric Cancer in Tikur Anbessa Specialized University Hospital Radiotherapy Unit from 2012 to 2017
    (Addis Ababa University, 2020-05) Dandena Yonas; Tigeneh Wondimagegnehu
    Background: Gastric cancer is one of the most common alimentary tract cancers. Due to environmental and dietary factors, its incidence is on the rise, especially in the developing world. There is a lack of published studies on gastric cancer in Ethiopia. Objective: To evaluate pattern of gastric cancer among patients coming to Tikur Anbessa Specialized Hospital, Radiotherapy Center from 2012-2107 G.C. Methodology: The record of all patients taken from the departments inpatient and outpatient log book who were registered in the department from January 2012- December 2017 was taken as the source population and those patients who were labeled as gastric cancer was taken as the study population. The information was collected by the principal investigator. Data were compiled and analyzed using IBM SPSS version 22 software and presented using tables and figures. Results- A total of 42 patients who fulfilled the inclusion criteria were enrolled in the study. The male to female ratio was 2:1. Patient ages ranged from 24 to 75 years. The majority (42%) of the patients aged 45-60. Abdominal pain was the most common initial clinical presentation accounting for (45.2%) of the cases. The majority (83.3%) had stage 4 disease at the time of the initial presentation. ECOG performance status 2 was recorded in (59.5%) of the patients. Known risk factors like alcohol and cigarette smoking were recorded in 14.3% and 2.4 % respectively. Antrum was the most common tumor site involved in 35.7% of the patients. The majority of the patients were evaluated with upper GI endoscopy (95.2%). Of the surgical procedures done on the study population palliative bypass gastrojejunostomy was the most frequent procedure (50%). Palliative combination chemotherapy was given to (69%) of the patients. Pain medications were given to (50%) of the patients. Conclusion/recommendation: The study has shown gastric cancer affects a diverse group of patients in terms of age, sex, place of living, marital status, and religion. The majority of the patients had an advanced stage of disease after presenting with a protracted duration of symptoms were palliative combination chemotherapy was the only treatment option. We recommend proper pathological and clinical documentation.