Browsing by Author "Beyene, Alemseged (MSc, Assistant professor of clinical pharmacy)"

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    Impact of Medication Therapy Management Interventions on Drug Therapy Problems, Medication Adherence, and Treatment Satisfaction among Ambulatory Heart Failure Patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2019
    (Addis Abeba University, 2020-06) Wondesen, Abate; Prof.Engidawork, Ephrem (PhD, Professor of Pharmacology); Beyene, Alemseged (MSc, Assistant professor of clinical pharmacy); Dr. Mekonen, Desalew( Internist, Cardiologist)
    Medication therapy management (MTM) interventions are a promising way to manage a complex disease like heart failure (HF). Medical therapy of HF has become increasingly complex which make HF patients are at high risk for developing drug therapy problems (DTPs) and medication non-adherent. This study aimed to assess the impact of MTM intervention on DTPs, medication adherence, and treatment satisfaction among ambulatory HF patients. A quasi-experimental study was conducted among 423 HF patients. Cipolle et al. DTP classification schemes used to classify DTPs. Medication adherence was determined using the eight-item Morisky medication adherence scale, and drug-drug interactions were assessed using Micromedex drug interaction checkers. The data were entered in Epidata version 4.2.0 and analyzed using SPSS version 25.0 statistical software. Descriptive statistics such as mean, percent, and frequency were used to summarize patients‟ characteristics. Univariable and multivariable linear regression was used. In the pre-intervention phase, 288 DTPs were identified with a mean (SD) of 1.3±1.1. A significant reduction of DTPs (0.67± 1.1, p<0.001) was observed in the postintervention phase compared to the pre-intervention phase. The most frequently identified DTPs in the pre-intervention phase were drug-drug interactions (47.6%) and nonadherent (37.3%). In the post-intervention phase, medication adherence improved from 73% to 89 % (95% CI of difference (1.17, 1.43), t= 20.17, p<0.001). This study found MTM interventions significantly reduced DTPs, and improved medication adherence and treatment satisfaction among HF patients.