Impact of Medication Therapy Management Interventions on Drug Therapy Problems, Medication Adherence, and Treatment Satisfaction among Ambulatory Heart Failure Patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2019
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Date
2020-06
Authors
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Publisher
Addis Abeba University
Abstract
Medication therapy management (MTM) interventions are a promising way to manage a
complex disease like heart failure (HF). Medical therapy of HF has become increasingly
complex which make HF patients are at high risk for developing drug therapy problems
(DTPs) and medication non-adherent. This study aimed to assess the impact of MTM
intervention on DTPs, medication adherence, and treatment satisfaction among
ambulatory HF patients. A quasi-experimental study was conducted among 423 HF
patients. Cipolle et al. DTP classification schemes used to classify DTPs. Medication
adherence was determined using the eight-item Morisky medication adherence scale, and
drug-drug interactions were assessed using Micromedex drug interaction checkers. The
data were entered in Epidata version 4.2.0 and analyzed using SPSS version 25.0
statistical software. Descriptive statistics such as mean, percent, and frequency were used
to summarize patients‟ characteristics. Univariable and multivariable linear regression
was used. In the pre-intervention phase, 288 DTPs were identified with a mean (SD) of
1.3±1.1. A significant reduction of DTPs (0.67± 1.1, p<0.001) was observed in the postintervention
phase
compared
to
the pre-intervention
phase.
The
most
frequently
identified
DTPs
in the pre-intervention phase were drug-drug interactions (47.6%) and nonadherent
(37.3%). In the post-intervention phase, medication adherence improved from
73% to 89 % (95% CI of difference (1.17, 1.43), t= 20.17, p<0.001). This study found
MTM interventions significantly reduced DTPs, and improved medication adherence and
treatment satisfaction among HF patients.
Description
Keywords
Heart Failure, Medication Therapy Management, Drug Therapy Problem, Medication Adherence, Treatment Satisfaction, Tikur Anbessa Specialized Hospital