Browsing by Author "Baye, Gelagey"

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    Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter Pylori Infection
    (Addis Abeba University, 2021-06) Baye, Gelagey; Menon, Menakath (Ph.D.); Gizaw, Solomon Tebeje(PhD)
    Introduction: H. pylori are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict cardiovascular disorders, we are evaluating and comparing lipid profile and hs-CRP levels between H. pylori-positive and negative patients. Objectives: To evaluate lipid profile and hs-CRP levels in dyspeptic patients with and without H. pylori infection. Methods: Hospital-based comparative cross-sectional study was conducted from September 2020 – January 2021 at Debre Markos town. Fifty H. pylori-positive and 50 H. pylori-negative patients were included. Socio-demographic data were assessed by using a structured questionnaire and it was checked for completeness and entered into SPSS version 25.0 Software. Both descriptive and inferential statistics were used in our study. The association between variables was determined by the chi-square test and Pearson correlation. Serum lipid profiles were compared by using a t-test and one-way ANOVA between groups but, hs-CRP levels were compared by using Mann-Whitney U-test between groups since the data wasn’t follow normal distribution. A p-value < 0.05 was considered statistically significant. Result: The mean serum HDL values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL for H. pylori-positive and negative dyspeptic patients, respectively, and the median of serum hs-CRP levels were 6.29 mg/L and 3.35 mg/L for H. pylori-positive and negative dyspeptic patients, respectively, with the p-value < 0.05 for both HDL and hs-CRP levels. Conclusion: Serum HDL levels were significantly lower in H. pylori-positive dyspeptic patients than negative dyspeptic patients, but serum hs-CRP levels were significantly higher in H. pyloripositive dyspeptic patients than negative dyspeptic patients. Therefore, H. pylori-positive dyspeptic patients are potentially at higher risk for cardiovascular diseases than the negative.