Browsing by Author "Asmellash Senait"

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    Bioactive Metabolites from Cultures of Two Species Of Higher Fungi
    (Addis Ababa Universty, 1991-12) Asmellash Senait; Dagne Ermias (PhD)
    Higher fungi collected from Central and Southern Ethiopia were investigated. The ethyl acetate extracts of submerged cultures of fifty fungi were screened for antimicrobial activity and lethality to brine shrimp (Artemia salina). Trametes pubescens and an Agaricus sp. were chosen for further chemical studies of the bioactive metabolites. Larger scale cultivations of these two species were made and the bioactive secondary metabolites were isolated, the structtlres of which were characterized by spectroscopic methods and chemical transformations. T. pl.lbescens yielded an antifungal compOlmd which was characterized as trans-2,3-epoxy deca-4,6,8-triyn-l-ol. Literature search revealed this compound to be reported for the first time. The Agaricus sp. afforded a known compound responsible for the fungal culture's lethality to brine shrimp and identified as monocerin, which appeared to be the first report from Agaricus species