Bioactive Metabolites from Cultures of Two Species Of Higher Fungi
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Date
1991-12
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Addis Ababa Universty
Abstract
Higher fungi collected from Central and Southern Ethiopia were investigated.
The ethyl acetate extracts of submerged cultures of fifty fungi were screened
for antimicrobial activity and lethality to brine shrimp (Artemia salina).
Trametes pubescens and an Agaricus sp. were chosen for further chemical
studies of the bioactive metabolites. Larger scale cultivations of these two
species were made and the bioactive secondary metabolites were isolated, the
structtlres of which were characterized by spectroscopic methods and chemical
transformations.
T. pl.lbescens yielded an antifungal compOlmd which was characterized as
trans-2,3-epoxy deca-4,6,8-triyn-l-ol. Literature search revealed this
compound to be reported for the first time. The Agaricus sp. afforded a known
compound responsible for the fungal culture's lethality to brine shrimp and
identified as monocerin, which appeared to be the first report from Agaricus
species
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Keywords
Higher fungi