Browsing by Author "Alemu, Asnakech"

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    Evaluation of the Analgesic and Anti-inflammatory Activities of 80% Methanol Extract of Leonotis Ocymifolia (Burm.f.) leaves
    (Addis Ababa University, 2017-06) Alemu, Asnakech; Shibeshi, Workineh(PhD); Nedi, Teshome (PhD)
    Pain and inflammation are the most common health problems treated with traditional remedies which mainly comprise medicinal plants. Leonotis ocymifolia is one of the medicinal plants used in folkloric medicine of Ethiopia for years to treat various pain and inflammation disorders. However, the plant has not been scientifically evaluated for the claimed activities. The aim of the present study was to evaluate the anti-inflammatory and analgesic activities of the 80% methanol extract of Leonotis ocymifolia leaves using rodent models. The central and peripheral analgesic activity of the extract was evaluated by using Eddy‘s hot plate method and acetic acid-induced writhing, respectively. The anti-inflammatory activity of the extract was evaluated by using carrageenan-induced paw edema and cotton pellet granuloma method. The study was carried out in three different dose levels of extracts 100,200 and 400mg/kg orally. The extract did not produce any mortality up to 2000mg/kg. In the hot plate method, the extract at all doses showed a significant (p<0.001) dose dependent analgesic effect with latency response of 32.8%, 47.9%, and 62.8% respectively, and inhibition of acetic acid induced writhings in mice was also observed with extract at all dose levels. Maximum anti-inflammatory effect by the 100, 200 and 400 mg/kg of extracts were observed at 6h post-induction, with respective values of 46.3%, 69.13 %, and 75.88%, in carrageenan-induced paw edema and all tested doses of extract significantly inhibited the formation of inflammatory exudates (p < 0.001) and granuloma formation (p < 0.001 ). Presence of saponins, alkaloids, flavonoids, tannins, terpenoids and phenols might be responsible for these activities and which are probably mediated via inhibition of various autacoids formation and release. In conclusion, the data obtained from the present study indicates that the extract possessed a significant analgesic and anti-inflammatory activity, upholding the folkloric use of the plant. Key words: Leonotis ocymifolia, analgesic, anti-inflammatory activity, 80% methanol extract and mice.
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    Migration and Household Income Diversification; The Case of Hetosa District, in Oromia Region
    (Addis Ababa University, 2014-06) Alemu, Asnakech; W/Hanna, Tassew (PhD)
    This paper uses limited-dependent variable methods and new data from Hetosa district to test the effect of intercontinental on activity choice and incomes in rural households. Econometric evidence supports our theoretical expectation that the impact of emigration varies both by migrant destination and production activity. We find no evidence of either positive or negative effects of continental migration on any activity because of all migrants are intercontinental migrants. However, intercontinental migration, which tends to be long term and generates significantly larger remittances, stimulates livestock production and cash crop while being negatively associated with non-farm activities income and positive associated with crop production but not significant .policy recommendation is very important to continuous the effect of migrant on income diversification i.e on livestock and cash crop production promotion of production working on infrastructure and search of ground water for irrigation is most policy recommended to district.