Anaesthesia and Anaesthesiology

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Browsing Anaesthesia and Anaesthesiology by Author "Abebe, Fasil"

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    Effectiveness of intra operative intravenous dexamethasone on post-operative opioid consumption in patients who undergo major orthopedic surgeries under general anesthesia at black lion hospital in Addis Ababa, Ethiopia 2018/19
    (Addis Ababa University, 2019-05) Abebe, Fasil; admassu, Wosenyeleh; woldemaryam, Lemlem
    Background: Dexamethasone is a powerful anti-inflammatory and anti-emetic agent that has been found to decrease opioid use and pain intensity. Effective postoperative pain control is an essential component of the care to the surgical patient. This study has been designed to investigate whether dexamethasone can be a good anesthetic adjuvant, in relation to decreasing the demand for post-operative analgesics and pain intensity. Objectives: To test the effectiveness of intravenous Dexamethasone on decreasing post-operative opioid requirements at black lion hospital, Ethiopia. Methods: The study was a prospective cohort study carried out at black lion hospital from September 21/2018 – May 20 /2019. A total of 66 patients for elective orthopedics surgery under general anesthesia were studied. Simple random sampling was used. The data were analyzed using independent sample t-tests and Manny Whitney u test for normally and non-normally distributed data respectively. Chi Square test was used to study the categorical variables. Box and Whisker plot were used to show a median pain score between groups and statistical significant were stated at P-value <0.05 with a power of 80%. Result: Decreased total analgesic consumption was observed in dexamethasone group 2.5 (1.25-5) as compared to control group 10 (5-10) mg with a P value of (P <0.0001). At all the time interval low pain score was observed in dexamethasone group with a P-value of <0.05. However there was no difference between the two groups at 3rd hour (P=0.586). The median time to first dose of analgesics in dexamethasone group was observed to be longer than control group 180 (120-240) minutes as compared to 60 (60-180) minutes. Conclusion and recommendation; dexamethasone administered after intubation, was better in reducing total opoid consumption, VAS score and first analgesic request time compared with the control group who takes nothing as adjuvant in patients undergoing general anesthesia for major orthopedics surgeries. Therefore, using dexamethasone intraoperatively to reduce opoid consumption especial during postoperative time is essential. Further randomized control trial study may be needed.