Pharmacy Practice

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Browsing Pharmacy Practice by Author "Alebachew, Minyahil (B.Pharm, M.Sc., Assistant Professor)"

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    Colorectal cancer treatment outcome and associated factors among patients treated at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
    (Addis Abeba University, 2020-10) Atsebeha, Berhan; Alebachew, Minyahil (B.Pharm, M.Sc., Assistant Professor); Dr.Aman, Munir Awol (MD, Oncologist)
    Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second cause of cancer death worldwide. It is a major public health problem and continues to be a disease of both the developed and developing nations. The objective of this study was to determine five year’s survival and associated factors among patients treated for CRC at adult oncology unit of Tikur Anbessa Specialized Hospital (TASH). A hospital based retrospective cohort study was conducted and all patient charts with diagnosis of CRC from September 11, 2013 to September 10, 2014 were included for the study and tracked until September 10, 2019. The data was entered and analyzed using SPSS version 23.0. Survival curves were plotted using Kaplan-Meier method and prognostic factors for survival were determined using Cox regression model. Out of the 316 CRC patients, 181(57.3%) were male with 1.34 ratio. The mean age in years was 48.66 + 13.58. Majority 115 (36.4%) of the patients were diagnosed with colon cancer, whereas, 112 (35.4%) and 89 (28.2%) patients were diagnosed with rectal and colorectal cancer respectively. Approximately, half (45.60%) of the patients were diagnosed at clinical Tumor Nodes Metastasis (TNM) stage-IV and 203 (64.2%) of patients were dead in the five years follow-up period with median survival of 19 months. The result of cox proportional hazard regression analysis showed that, being underweight (HR=1.72, 95% CI (1.19-2.48)), rectal cancer (HR=1.92, 95% CI (1.382.68)) and late stage of CRC (HR=2.71, 95% CI (1.67-4.41)) were associated with decreased survival. This study reflects that most patients diagnosed with CRC at TASH were predominantly presented at advanced stage and treatment outcome was poor compared to many African studies. Hence, a concerted effort has to be made to improve access to specialized medical faculties and public health education programs on CRC, which may be necessary for early detection and thereby improve treatment and CRC survival.