Pharmacology

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Browsing Pharmacology by Author "Ahmed, Abdurezak (Assistant Professor)"

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    Assessment of Antidiabetic Medication Adherence and Its Effect on Glycemic Control in Ambulatory Patients with Type 2 Diabetes at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
    (Addis Ababa University, 2014-12) Tsehay, Tessema; Engidawork, Ephrem (PhD); Ahmed, Abdurezak (Assistant Professor)
    Poor adherence to treatment of chronic diseases is a worldwide problem of striking magnitude. Adherence to long-term therapy for chronic illnesses in developed countries averages 50%. In developing countries, the rates are even lower given the paucity of health resources and inequities in access to health care. Poor adherence to recognized standards of diabetes care is the principal cause of development of complications of diabetes and their associated individual, societal and economic costs. Information on adherence to antidiabetic medications and glycemic control among Type 2 diabetes patients in Ethiopia is scanty. This study therefore sought to assess antidiabetic medication adherence and glycemic control among 322 ambulatory patients with Type 2 diabetes mellitus attending at the diabetic clinic of Tikur Anbessa Specialized Hospital (TASH). The study was a two phase, cross-sectional study conducted between 1 May-30 June 2014. Assessment of adherence was performed based on patients’ response to the validated four-item Morisky instrument and the most recent fasting blood sugar level was used for glycemic control. Adherence rate to antidiabetic medications was found to be 66.8%. Younger age, increased number of prescribed medications and job type (being a farmer/daily laborer) were significantly associated with antidiabetic medication noniv adherence. Most of the patients missed their medications because of forgetfulness. On the other hand, only 12.7% of patients attained adequate glycemic control. Male sex, younger age, low educational status, regular alcohol intake, exercise and dietary non-adherence were observed to be significantly associated with poor glycemic control. Antidiabetic medication adherence appeared to be positively associated with glycemic control (COR= 1.23, 95% CI: 0.6-2.5). Taken together, the findings indicated that adherence to antidiabetic drugs was suboptimal and glycemic control was poor, which warrants the need for health care providers engaged in diabetic care to aggressively address the issue. Key words: Antidiabetic Medications, Adherence, Type 2 Diabetes, Glycemic control, Fasting Blood Glucose