Epidemiology

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Browsing Epidemiology by Author "Addissie, Adamu(MD, PhD)"

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    Validity of the European organization for research and treatment of cancer quality of life tools in colorectal and oesophagogastric cancer patients in Ethiopia, 2020.
    (Addis Abeba University, 2020-06) Genene, Lidya; Addissie, Adamu(MD, PhD); Wondimagegnehu, Abigiya(MPH, PhD can.); Abraha, Aynalem(MD)
    Background- Gastro intestinal cancers and their treatments have detrimental effect on patients’ Quality of Life. The European Organization for Research and Treatment of Cancer (EORTC) tools which had been developed to assess quality of life among colorectal and oesophagogastric cancers patients were validated and used in different countries. However, the tools have not been translated into local language nor validated in Ethiopian context. Therefore, this study aimed to validate EORTC quality of life tools in Ethiopian colorectal and oesophagogastric cancer patients. Methods: Institution based cross-sectional study was done at Tikur Anbessa Specialized Hospital from March to May, 2020. Based on the recommendations given for multi trait scale analysis, 158 colorectal and 158 oesophagogastric cancer patients at the time of data collection period were consecutively included. SPSS version 21 was used for the analysis. The validity and reliability were evaluated in terms of acceptability, internal consistency, face validity,convergent, divergent, clinical validity and unidimensionality of the tools. Result: Among the participants 52.2% were male. The median age of the participants was 48(IQR =17.75). The alpha values ranged from 0.47- 0.91 and 0.39 - 0.7 for colorectal and oesophagogastric tools, respectively. Multi trait scale analysis showed that all items correlations within their scales were greater than 0.4 except for blood and mucus in stool,dysphagia, eating and odynophagia scales. The value of correlation coefficients between all items and their own domain were higher than other domains except for eating, odynophagia,dysphagia, anxiety, and blood and mucus in stool scales. The correlation between the core questionnaire and colorectal tool ranged from -0.46– 0.57. Similarly, oesophagogastric and the core questionnaire correlation extended from -0.65-0.62. The tools also discriminated among clinically distinct groups. Conclusion: Even though the tools’ clinical validity was supported, the convergent and divergent validity of eating, odynophagia, dysphagia, anxiety, and blood and mucus in stool scales were not supported. Thus, the finding suggested doing confirmatory factor analysis.