Evaluation of the Antidepressant-like Activity of the Crude Extract and Solvent Fractions of Rosa abyssinica Lindley (Rosaceae) Using Rodent Models of Depression
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Date
2014-06
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Addis Ababa University
Abstract
Depression is a disorder often manifested with symptoms at the psychological, behavioral and physiological levels. Herbal medicine holds a valuable place in the treatment of depression. It is also a reasonable alternative for developing novel drugs. Accordingly, 80% methanol extract of the fruits of Rosa abyssinica Lindley (Rosaceae) and its solvent fractions were assessed for their antidepressant-like effect using despair based models of depression including tail suspension test (TST) and forced swim test (FST). The effect of the crude extract on the locomotor activity was also assessed using the open field test (OFT).
Animals were randomly assigned to five groups, (n=8). Negative control group received 2% Tween 80, whereas positive control group received imipramine (30 mg/kg). The test groups received 100 mg/kg, 200 mg/kg and 400 mg/kg of the crude extract or the solvent fractions of Rosa abyssinica. The crude extract at the doses of 200 mg/kg and 400 mg/kg significantly reduced the time of immobility (p<0.01) in the TST and FST. The aqueous fraction at 200 mg/kg displayed a significant reduction (38%, p<0.01) in time of immobility in TST which was superior to the effect of imipramine. The methanol fraction displayed a significant reduction in the duration of immobility (33.93%, p< 0.01) only at 200 mg/kg. Interestingly the ethyl acetate fraction was devoid of activity. No significant change in locomotor activity was detected in all the doses of the crude extract and imipramine in OFT. These results suggest that this plant holds a potential value for the management of depression.
Keywords: Rosa abyssinica Lindley (Rosaceae), Depression, Antidepressant, crude extract, solvent fractions
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Keywords
Rosa abyssinica Lindley (Rosaceae); Depression, Antidepressant; Crude extract; Solvent fractions