Assessment of Ceftriaxone Utilization in Different Wards of Federal Police Referral Hospital; A Retrospective Study
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Date
2015-01
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Addis Ababa University
Abstract
The irrational use of antimicrobials such as ceftriaxone is one of the current public health issues. The problem becomes twofold when it happens in low income countries like Ethiopia. The objective of this study is to assess the utilization of ceftriaxone in different wards of FPRH, Addis Ababa. An institution based retrospective cross sectional study design was used to evaluate the use of ceftriaxone. The assessment was done by reviewing medication records of patients who received ceftriaxone during hospitalization in the different wards of Federal Police Referral Hospital from 1 May, 2013 to 30 April, 2014. A systematic random sampling technique was used to select the samples from all the inpatient prescriptions containing ceftriaxone. Patient medication records/ charts were located based on the medical record number on the prescription papers. Data was collected by using a structured format and evaluated against the Standard Treatment Guideline of Ethiopia as well as the IDSA and ASHP guidelines. Out of the 682 patient medication records sampled, 571 were found to be complete and subsequently evaluated against the guidelines. Ceftriaxone was prescribed for 2048 (44.3%) of the 4423 admissions in the respective wards. Overall evaluation of ceftriaxone therapy for indication, dose, frequency and duration revealed that 346 (60.6%) of the patient medication records were compliant to recommendations set in the guidelines. Frequently noted non-compliant uses included continued uses as pre & post-operative prophylaxis, unsupported indication in certain
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diagnoses and deviated duration of therapy in medical cases. Among the co-prescribed medications checked for potential interaction with ceftriaxone, warfarin, heparin and doxycycline were found to have a significant drug-drug interaction. Days of hospital stay, type/payment scheme of medical service and type of ward patients had been admitted in were the factors associated with compliant ceftriaxone use in FPRH. The compliance of ceftriaxone utilization in FPRH, to the guidelines, is moderate. However, all concerned bodies and the hospital should be engaged for developing antimicrobial guideline, provide ongoing trainings, establishing a DIC and promote health professionals‟ adherence to the national STG to fill the remaining gap.
Key words: Drug use evaluation, Ceftriaxone, Federal police referral hospital.
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Keywords
Drug use evaluation; Ceftriaxone; Federal police referral hospital.