Seroprevalence of Herpes Simplex Virus (HSV) Type 2 in Adult Ethiopians: Its Association With HIV, HSV-L, Syphilis And Some Other Risk Factors
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Date
2001-05
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Addis Ababa University
Abstract
This paper reports a preliminary data on HSV type 2 and type I from a retrospective
cross sectional study on 1168 (530 female and 638 male) subjects aged 15-66, living
at Akaki and Higher 23 (located at the vicinity of All African Leprosy Educational
Research and Training (ALERT)), places around Addis Ababa, Ethiopia. The plasma
samples were tested for antibodies against HSV-2 and HSV-l, by using glycoprotein
g (gG2 and gGl) specific ELISA kit. Prevalence of antibodies against HSV type 2
was 44.5% (520/1168) in both sexes while the prevalence of antibodies against
HSV-l was found to be as high as 94.7% (2311244). HSV-2 serological data is
presented in the context of HI V, syphilis, genital ulcer, genital discharge and various
socioepidemiological information. An overall HSV-2 seroprevalence of 64%
(124/193) in women 35-44 years old and 50% (28/56) in men 45-66 years old were
determined. On the other hand seroprevalence of HSV-2 antibodies in women
seropositive for HIV-l antibodies was 80% (40/50) versus 47.5% (228/480) among
HIV -negatives. Among the HIV positive men, the prevalence was 70% (46/66) and
36% (206/572) in the HIV-seronegatives. HSV-2 seropositivity was 71.3% (72/101)
and 45.7% (196/429) in women seropositive and seronegative for syphilis antibodies
respectively. In the men, it was 60% (94/157) and 32.8% (158/481) among the
syphilis seropositives and syphilis-seronegatives respectively (P < 0.00 I). It was
concluded that being older, HIV seropositive, and syphilis seropositive, were
significantly associated (P < 0.05) with HSV -2 seropositivity in both sexes. Highly
significant (P < 0.05) association was observed between HSV -2 seroposititvity and
the various sociodemographic factors examined in both women and men sUbjects.
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Biology