Evaluation of Hematological and Lipid Profiles in Pulmonary Tuberculosis Patients: A case control Study at Metema and Gondar Referral Hospitals, North West Ethiopia
No Thumbnail Available
Date
2017-08
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Background: Tuberculosis is one of the first most common causes of deaths in the world
alongside HIV/AIDS, causing more than 9.6 million new cases and 1.5 million deaths globally in
2014 alone. This infection also accompanied by hematological and lipid profile alterations. The
hematological and lipid alteration related to the disease is not yet well determined and has
variation in different studies.
Objective: This study aimed at evaluating hematological and lipid profiles in pulmonary
tuberculosis patients in Metema hospital and Gondar referral Hospital, North West Ethiopia.
Materials and methods: A case control study design was implemented from January to July
2017. One to one case to control ratio was used and a total of 88 blood samples were collected.
There were 44 samples from tuberculosis patients and 44 samples from apparently healthy
individuals. Collected bloods were tested using Hematology analyzer (sysmex) and Mindray
chemistry analyzer for hematological and lipid profiles, respectively.
Results: The mean + SD of hemoglobin, hematocrit and red blood cell count of the pulmonary
tuberculosis patients were significantly lower than control groups (P < 0.05). However, platelet
counts, total white blood cell counts, and erythrocyte sedimentation rate were significantly
increased as compared with control groups (p<0.05).The mean serum levels of triglyceride, total
cholesterol, high density lipoprotein and low density lipoprotein were significantly lower than
their respective control groups (p=0.001). Body mass index had significant positive associations
with RBC counts, HGB, and HCT and serum levels of TC and LDL (P < 0.05).
Conclusion: Pulmonary Tuberculosis patients in this study had hematological and lipid profile
abnormalities. RBC count, HCT and HGB were significantly reduced. However, TWBC count,
thrombocyte, and ESR of TB patients were significantly elevated than control group. Total
Cholesterol, HDL, LDL and TG concentrations were significantly reduced as compared with
control groups. The factors associated with hematological and Lipid profiles also due attention to
prevent further complication.
Keywords: Case, Control, Lipid profile, Hematological profile, Tuberculosis.
Description
Keywords
Case; Control; Lipid profile; Hematological profile; Tuberculosis.