Evaluation and Comparison of Serum Lipid Profiles Between Newly Diagnosed and Tamoxifen Treated Breast Cancer Female Patients Attending the Oncology Clinic at Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia
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Date
2017-08
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Addis Ababa University
Abstract
Background: Breast cancer is the most common cancer in women worldwide and the second most
common cancer overall. It is the leading cause of cancer death in less developed countries
including Ethiopia. Dyslipidemia in breast cancer patients has long been considered as the risk
factor for cardiovascular diseases. Estrogen induces hyperlipidemia through its multiple effects on
lipid metabolism. Tamoxifen used for breast cancer treatment, is essentially anti-estrogenic,
however, currently, it has been suggested that its estrogenic activity is mainly responsible for the
changes in lipid parameters. Because marked hyperlipidemia is a potent risk factor for life-
threatening acute pancreatitis and arteriosclerosis, plasma lipid levels should be tested periodically
in breast cancer patients. However, detection of lipid profiles in newly diagnosed and tamoxifen
treated breast cancer women have not been investigated yet in our country, Ethiopia.
Objective: Therefore, the aim of this study was to evaluate and compare serum lipid profiles
between newly diagnosed and tamoxifen treated breast cancer women attending the oncology
clinic at TASH.
Patients and methods: Comparative cross-sectional study design was used to determine fasting
serum lipid profiles in newly diagnosed and tamoxifen treated women with breast cancer in the
oncology clinic of TASH. Convenience sampling method was applied to recruit study subjects and
52 breast cancer women treated with tamoxifen for three months and above and 51 new medically
diagnosed breast cancer women without treatment were included and serum lipid parameters (TG,
TC, HDL-C, and LDL-C) were measured.
Result: In breast cancer women receiving tamoxifen, the mean serum TC and LDL-C levels were
significantly reduced but TG levels were insignificantly decreased accompanied by the elevation
of HDL-C though it was insignificant as compared to those women with no treatment.
Conclusion: lipid profile is significantly improved upon tamoxifen treatment and this confirms
that tamoxifen has cardio protective roles in lipid metabolism
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Keywords
Tamoxifen Treated; Female Patients