The Prevalence of HIV/Malaria Co-Infection during Pregnancy in Adama Hospital and ‘Awash Sebat Kilo’ Health Center, Ethiopia
| dc.contributor.advisor | Petros Beyene (Professor) | |
| dc.contributor.author | Sime Heven | |
| dc.date.accessioned | 2018-07-02T13:11:30Z | |
| dc.date.accessioned | 2023-11-08T16:39:43Z | |
| dc.date.available | 2018-07-02T13:11:30Z | |
| dc.date.available | 2023-11-08T16:39:43Z | |
| dc.date.issued | 2009-06 | |
| dc.description.abstract | The study was undertaken to determine the prevalence and severity of malaria in HIV positive pregnant and non-pregnant women who receive antiretroviral therapy (ART). The level of malaria prevalence, disease severity (as measured by parasite density and Hb level); and immune status (as measured by CD4+± T cell count) were determined for 500 HIV positive women from Adama hospital and ‘Awash Sebat Kilo’ health center. 18.4% of the HIV positive women were pregnant and a total of 22.2% were malaria infected. Among the pregnant HIV positive women, 44.6% were malaria infected. Compared to the non-pregnant HIV/malaria co-infected, pregnant HIV/malaria co-infected women, on the average, had a significantly higher (P<0.001) parasite densities (26,59515,309 versus 15,400±12,278) and a significantly (P=0.05) lower Hb values (7.49±3.34 versus 8.37±3.13). The HIV/malaria co-infected pregnant women also had a lower, but statistically non-significant, mean CD4+ T cell count (195±123 versus 220±140) than the non-pregnant HIV/malaria co-infected women. Compared to pregnant women infected with only HIV, malaria/HIV co-infected pregnant women had significantly lower (P=0.005) CD4+± T cell count (195123 versus 279±151) and significantly lower (P<0.001) mean Hb level (7.49±3.34 versus 10.53±2.96). Lower CD4+ T cell count and Hb level and higher parasite density were recorded in primigravid HIV/malaria co-infected pregnant women than in the multigravid ones. Furthermore, a significant improvement in the mean CD4+ T cell count, Hb level and parasite density for HIV/malaria co-infected pregnant women was observed with increasing duration of the use of ART. That is, receiving ART for more than 6 months improved the health condition of HIV/malaria co-infected pregnant women whereby their CD4+ Key words: Malaria, HIV, HIV/malaria co-infection, Pregnancy, Severe malaria, ART T cell count and Hb levels were increased and malaria parasite densities were decreased (P=0.001). The study on the whole has indicated that, in malaria endemic areas, extra care must be taken to protect HIV positive pregnant women from malaria infection. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/5521 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Malaria | en_US |
| dc.subject | HIV/malaria co-infection | en_US |
| dc.subject | Pregnancy | en_US |
| dc.subject | Severe malaria | en_US |
| dc.subject | ART | en_US |
| dc.title | The Prevalence of HIV/Malaria Co-Infection during Pregnancy in Adama Hospital and ‘Awash Sebat Kilo’ Health Center, Ethiopia | en_US |
| dc.type | Thesis | en_US |