Anti inflammatory and bacterial effect of Arthrospira plathensis (Spirulina) on Schistosomiasis mansoni and Selected Human Bacterial Pathogens
| dc.contributor.advisor | Lakew, Mekuria (PhD) | |
| dc.contributor.author | Sileshi, Abraham | |
| dc.date.accessioned | 2018-06-13T09:10:22Z | |
| dc.date.accessioned | 2023-11-08T16:39:39Z | |
| dc.date.available | 2018-06-13T09:10:22Z | |
| dc.date.available | 2023-11-08T16:39:39Z | |
| dc.date.issued | 2011-02 | |
| dc.description.abstract | Arthroscopic platen sis (spirulina) is multi cellular filamentous blue green alga that is abundantly found in lakes of high salinity in Ethiopia. Several studies have shown that it has importance in human health and nutrition. The health benefits of spirulina relies mainly on tits anti-inflammatory, anti- oxidant and antimicrobial properties. In the current study spirulina wasstudied for its anti-inflammatory and antimicrobial effects using change in size and number of S.mansoni induced granular in infected mice and inhibitions of known human bacterialpathogens (S. typhi, S. dysenteriae, E. coli, S. aureus, S. epidermidis, C. freundii, and P.aeruginosa) as parameters. S. mansoni is a parasitic helmintic infection with high public healthimportance next to malaria, HIV-AIDS and TB especially in sub Saharan countries. Chronicinflammatory response in response to S. mansoni egg trapped in liver tissue is the mainpathology responsible for the morbidity and mortality associated with the disease.Methodologies used in the study involve S. mansoni infection of Swiss albino mice, treatment ofexperimental animals with spirulina at two doses 100 and 400 mg/kg through oral, rectal, andoral/rectal. Animal dissection and histological staining of the liver to measure granulomadiameter, and finally antibiotic sensitivity test using disk diffusion method was done.Independent T. test comparison of the measurements form the anti-inflammatory test showed that the size of granular around an egg from spiritual treated compared to controls was significantly reduced. In association with this, comparison between different treated groups showed that treatment through oral route at a dose of 400 mg/ kg scores the highest percentage reduction both in granular size (59.53%) and granular number (72%). Result from the antimicrobial study showed that all test organisms except S. typhi were susceptible for the water suspension and extracts of spiritual unlike that of the Methanol extract. The possible explanations are discussed. In conclusion and recommendation the anti-inflammatory and antimicrobial effect of spiritual are summarized and future direction of research indicated Key words: - Spirulina, S. mansoni, Granuloma, Anti-inflammatory, Antimicrobia | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/675 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Spirulina | en_US |
| dc.subject | S. mansoni | en_US |
| dc.subject | Granuloma | en_US |
| dc.subject | Anti-inflammatory | en_US |
| dc.subject | Antimicrobia | en_US |
| dc.title | Anti inflammatory and bacterial effect of Arthrospira plathensis (Spirulina) on Schistosomiasis mansoni and Selected Human Bacterial Pathogens | en_US |
| dc.type | Thesis | en_US |