Incidence and predictors of attrition among children on anti-retroviral therapy at Gedeo zone selected public hospitals, SNNPR, 2020
| dc.contributor.advisor | Sebsibie, Girum (Assistant Professor) | |
| dc.contributor.advisor | Sr. Wondwossen, Kalkidan (BSc, MSc) | |
| dc.contributor.author | Bimer, Kirubel | |
| dc.date.accessioned | 2020-12-13T07:35:17Z | |
| dc.date.accessioned | 2023-11-06T09:02:06Z | |
| dc.date.available | 2020-12-13T07:35:17Z | |
| dc.date.available | 2023-11-06T09:02:06Z | |
| dc.date.issued | 2020-09 | |
| dc.description.abstract | Background: Human immune deficiency virus (HIV) is one of the world‟s most serious public health challenges. However, the expanded access to antiretroviral therapy has led to an intense reduction in HIV related morbidity and mortality among children. Despite this remarkable achievement, the attrition of children from ART care has remain challenging. Objective of the study: To assess the incidence and predictors of attrition among children on antiretroviral therapy in Gedeo zone public hospitals, Southern Ethiopia, 2020. Method: Retrospective follows up study was employed among 254 systematicaly selected children <15 years who were receiving ART in Gedeo zone public hospitals. The total sample size was calculated using Epi Info version 7. Data were collected using data extraction tool. Data were cleaned and edited before analysis and then entered into epidata manager version 4.6 and exported to Stata version 14 for analysis. Data were described using Kaplan-Meier curve, log rank test, life table and crude hazard ratios. Predictors of attrition assessed using Cox proportional hazards model. Covariates with p-values (<0.25) in the bivariable analysis were included to multivariate analysis. Finally, a statistical significance was declared at pvalue <0.05. Data were presented using tables, figures, and texts. Results: The incidence rate of attrition was 11.3 per1000 person-months observation (95%CI: 9.20 -13.85) with a total of 8145.33 child-months observation. The median survival time was 68.73 months. Children with low hemoglobin levels (AHR = 3.5, 95% CI:1.6-7.4), low CD4 count (AHR=3.7, 95%CI:1.4- 9.7), delayed developmental stage (AHR=3.76, 95%CI:1.211), underweight (AHR=5, 95%CI:1.5-17.25) and poor/fair ART adherence levels (AHR=3.2, 95% CI:1.3-7.8) were at higher hazards of experiencing attrition. Conclusion and recommendation: The incidence rate of attrition was 11.3 per1000 personmonths observation. Low Hgb level (Hgb<10mg/dl), low CD4+count, underweight (WFAz < -2), delayed developmental stage and poor/fair ART adherence level were predictors of child attrition. So, early detection, close follow up, monitoring and management has to be strengthened particularly for patients with low CD4+ count, underweight and low haemoglobin level to reduce attrition from ART care. Improving adherence counseling and strengthen nurtritional support also crucial. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/23995 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | ART, Children, HIV/ADIS, Attrition, Incidence, Ethiopia | en_US |
| dc.title | Incidence and predictors of attrition among children on anti-retroviral therapy at Gedeo zone selected public hospitals, SNNPR, 2020 | en_US |
| dc.type | Thesis | en_US |