Synthesis and Characterization of Some Metal Complexes of Schiff bases Derived from Ninhydrin and a, L-Valine
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Date
2001-07
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Addis Ababa Universty
Abstract
Complexes of Mn (II), Fe (II), Co (II), Co (III), Ni (II) and Zn (II) with Schiff base
derived from ninhydrin and valine have been successfully synthesized. The complexes
were distinctly colored and were characterized by elemental analysis, molar conductance,
Infrared and electronic spectral studies. The ligands were found to act as a mono basic
tridentate, ONO donor.
Synthesis of metal complexes of the Schiff base derived from ninhydrin and cysteine was
unsuccessful.Variations between amino acids lie in the nature of side chain, which
confers individuality upon each amino acids. Thus studies on the side chain,-SH , were
done by taking in to consideration the properties of-SH group. With the assumption that
acidity of the group had an effect, acidic amino acid (tyrosine) was taken but the result
was positive. It showed that acidity was not the reason for cysteine not forming metal
complex. The other property considered was the soft sulfur group, since the metals used
in the synthesis were hard, other soft metal (Cd(II)) was taken with the cysteine schiff
base itself and it has formed a metal complex. Hence, the reason for not forming metal
complex with first row transition metal is due to the soft side chain, -SH group.
Comparative anti microbial study of the complexes with the starting material ninhydrin
was undertaken against three bacteria. Enhanced activity than ninhydrin on the two
bacteria were observed
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Keywords
Mn (II), Fe (II), Co (II), Co (III), Ni (II) and Zn (II)