Prevalence of Thrombocytopenia and its Associated Factors among Neonates Admitted to Neonatal Intensive Care Unit at Public Hospitals of Addis Ababa in 2020/21G.c.
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Date
2021-05
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Addis Abeba University
Abstract
Background Thrombocytopenia is one of the most frequent hematologic disorders encountered in the sickneonate. This is evidenced by a fairly high prevalence among neonates admitted to theneonatal intensive care unit 22%-35%, especially in very-low-birth-weight and pretermneonates its prevalence is up to 70%-80%. In Africa, the prevalence of neonatalthrombocytopenia in Nigeria is 53%, 12.4% in Tunisia, and 16.2% in Libya. However, inEthiopia, no study assessed both its prevalence and associated factors. This study assessed theprevalence of thrombocytopenia and its associated factors among neonates admitted toneonatal intensive care unit at public hospitals in Addis Ababa in 2020/21.
Methodology: Institution based cross sectional study was conducted at NICU of selectedAddis Ababa public hospitals from February 15thto March 15th, 2021. Single populationproportion formula is used to determine sample size. The final sample size is 423. Datacollected by using pretested, data extraction checklist for chart review by data collector. Thecollected data entered using Epi data and exported to SPSS version 25 for analysis. Variablesthat have P-value <0.05 in bivarite entered in to multivariable logistic regression model tocontrol for confounder. Statistical significance declared at p-value <0.05.
Results: The prevalence of neonatal thrombocytopenia in the study area is 66%.In this studyvariables such as eclampsia(AOR=4.8, 95%CI: 1.66-13.94), Prolonged rupture ofmembrane(AOR=0.26, 95%CI:0.101-0.669), Intra uterine growth retardation(AOR=0.26,95%CI: 0.1-0.68), neonatal sepsis (AOR=11.98, 95%CI: 4.023-35.7), Perinatalasphyxia(AOR=6.68, 95%CI: 1.616-27.6), Necrotizing enterocolitis (AOR=14.6, 95%CI:2.84-75.61) and prolonged nothing per oath(AOR=0.243,95%CI: 0.084-0.705) were factorsassociated with neonatal thrombocytopenia.
Conclusion and recommendation: Prevalence of neonatal thrombocytopenia in Addis Ababapublic hospitals neonatal intensive care unit is high. Therefore, identifying factors associatedwith it used as an input in reducing the problem.
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Neonate, thrombocytopenia, platelet, neonatal intensive care unit