Evaluation of Antihypertensive, Hypotensive and Antihyperlipidemic Activities of Aqueous Crude Extract of Thymus serrulatus Leaves in Rats
No Thumbnail Available
Date
2018-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa Universty
Abstract
Evaluation of Antihypertensive, Hypotensive and Antihyperlipidemic Activities of Aqueous Crude Extract of Thymus serrulatus Leaves in Rats
Hiwot Getachew
Addis Abeba University, 2018
In Ethiopia, the genus Thymus is represented by two indigenous species namely Thymus serrulatus and Thymus schimperi both of which are locally named as Tosign. Among numerous medicinal uses of T. serrulatus leaves treatments of renal diseases, liver diseases, hypertension and Tinea capiti are the most common. The main aim of the present study was to evaluate antihypertensive, hypotensive, hypolipidemic and antihyperlipidemic effects of the aqueous crude extract of Thymus serrulatus leaves and AQ residue against normotensive and fructose induced hypertensive rats. The blood pressure was measured from the tail of rats using non-invasive BP monitoring apparatus (Model 179, IITC Inc, U.S.A). Aqueous crude extract of Thymus serrulatus leaf and the AQ residue caused significant fall in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MABP) at doses of 250, 500 and 1000 mg/kg; in fructose induced hypertensive rats, where the highest reduction were seen by aqueous crude extract. The aqueous crude extract showed reduction of blood glucose and lipid profiles (Total cholesterol and Triglyceride) in a dose dependent manner. Aqueous residue at a dose of 1000 mg/kg showed comparable effect on alanine aminotransferase (ALT) compared with the Captopril treated groups and it also showed significant reduction compared to fructose induced hypertensive groups (p<0.05). The other liver parameter results were seen to have neither dose dependent pattern nor statistically significant difference with captopril treated groups and negative control (p> 0.05). The level of both urea and creatinine decreased dose dependently for all extracts; the higher doses of aqueous residue showed significant reduction compared to the negative control (p<0.01). The study findings indicate that Thymus serrulatus possesses a significant anti-hypertensive, anti-hyperlipidemic effects and kidney functions improvement; which may help in treatment of hypertension and its complication.
Description
Keywords
Hypertension, Thymus serrulatus, Antihypertensive effect, Antihyperlipidemic effect