The effect of rifapentine and isonized therapy on IGRA reversion and conversion among HIV positive individuals in Addis Ababa: a retrospective cohort study.
| dc.contributor.advisor | Yimer, Getnet (MD, Ph.D.) | |
| dc.contributor.advisor | Yismaw, Gizachew(MSC, Ph.D.) | |
| dc.contributor.author | Kidane, Achenef | |
| dc.date.accessioned | 2021-03-23T06:41:32Z | |
| dc.date.accessioned | 2023-11-06T08:10:35Z | |
| dc.date.available | 2021-03-23T06:41:32Z | |
| dc.date.available | 2023-11-06T08:10:35Z | |
| dc.date.issued | 2020-05 | |
| dc.description.abstract | Interferon-γ release assays (IGRAs) such as QFT gold plus is one of the main tools for the diagnosis of latent TB infection (LTBI). The main objective this study was to assess the effect of Rifapentin and Isoniazid (3HP) on IGRA reversion and conversion. IGRA reversion and conversion rates have generally been reported after preventive TB therapy, but rates vary widely depending on different settings and there was no study conducted in Ethiopia on IGRA reversion and conversion in post 3HP. A retrospective cohort study of 519 human immunodeficiency virus (HIV) positive individuals who had follow up at Zewditu and Alert Hospitals in Addis Ababa, Ethiopia underwent testing with QuantiFERON (QFT) gold plus at enrolment and 12-month follow-up after taking Rifapentine and Isoniazid (3HP) prophylaxis therapy were included in the final analysis in this study to assess the reversion and conversion of IGRA. The rate of IGRA reversion among LTBI positives and the rate of conversion among latent Tuberculosis infection (LTBI) negative at baseline was 67/169 (39.6 %) and 66/350 (18.9 %) respectively. The observed high IGRA conversion rates indicated a higher rate of Mycobacterium TB infection among LTBI negative patients despite taking 3HP. The prevalence of LTBI among HIV positive individuals was found to be 169/519 (32.6 %; 95% CI 28.5% to 36.5%). Having a history of tuberculosis is substantially associated with LTBI (AOR=1.7 [95% CI 1.15, 2.52]). IGRA reversion rate after taking Rifapentin – INH prophylaxis therapy was fairly high and the rate of IGRA conversion was high despite taking the tuberculosis prophylaxis. Hence targeted screening approach for diagnosing latent tuberculosis infection in HIV/AIDS patients using appropriate methods before administration of TB preventive therapy is recommended. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/25624 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Rifapentine, isonized therapy ,IGRA reversion ,HIV positive | en_US |
| dc.title | The effect of rifapentine and isonized therapy on IGRA reversion and conversion among HIV positive individuals in Addis Ababa: a retrospective cohort study. | en_US |
| dc.type | Thesis | en_US |