Postsurgical Assessment of Serum Interleukin-6 and C-reactive protein in Breast Cancer Patients before Receiving Adjuvant Chemotherapy
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Date
2016-06
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Publisher
Addis Ababa University
Abstract
Background: Breast cancer is one of the most common cancers in females. Several
studies have shown proinflammatory biomarkers can facilitate tumor growth and
metastasis by altering tumor cell biology and activating stromal cells in the tumor
microenvironment. They have been also associated with poor survival of breast
cancer patients.
Objective: The aim of this study was to evaluate postsurgical serum interleukin 6 and
C reactive protein in breast cancer patients before receiving chemotherapy in Tikur
Anbessa specialized teaching hospital, Ethiopia.
Methodology: A hospital based cross sectional study design and a convenient non-
probability sampling technique were applied in this study. Forty-four breast cancer
patients visiting oncology chemotherapy unit were identified for the study and were
subjected to assessment. Serum interleukin-6 and c –reactive protein values were
measured before initiation of adjuvant chemotherapy in breast cancer patients using
an
ElectroChemiLuminescencetechnology
(ELC)
assay
technique
and
immunoturbidimetric respectively.
Result: A total of 44 cases were included in the study. The median age was 42 years,
the majority of patients had invasive ductal carcinoma, and did present with positive
nodes involvement. Postsurgical elevated levels of serum CRP and IL-6 were
observed in most of the patients. Progress in breast cancer staging were associated
with increases in serum IL-6. IL-6 level correlated with stage (P < 0.026), CRP has
borderline correlation with stage (p = 0.05). However, IL-6 and CRP have shown
insignificance correlation with tumor size and lymph node involvement. Serum IL-6
levels were correlated positively with CRP levels (rho = 0.530, p < 0.01).
Conclusion: These results suggest that proinflammatory status of the breast cancer
patient have high values of interleukin-6 and C– reactive protein. Progressive
elevation of serum interleukin 6 observed as stage of cancer advanced.
Key words: interleukin-6, C - reactive protein, breast cancer, proinflammatory
Description
Keywords
Interleukin-6; C - reactive protein; Breast cancer; Proinflammatory