Association of Metabolic Syndrome and Cardiovascular Risk factors Among Colorectal Cancer Patients Attending in Tikur Anbessa Specialized Hospital Oncology Units
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Date
2017-06
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Addis Ababa University
Abstract
Background: Metabolic syndrome and obesity are risk factors for developing type 2
diabetes mellitus and/or cardiovascular disease, especially stroke. Obesity-associated
diseases account for a large portion of public health challenges. Among obesity-related
disorders, a direct and independent relationship has been ascertained for colorectal
cancer.
Objective: The aim of this study was to determine the prevalence of metabolic syndrome
and other cardiovascular risk factors, including dyslipidemia, hypertension, dietary and
exercise practices, tobacco use and body mass index in individual with colorectal cancer
patients attending Tikur Anbessa Hospital Oncology department, Addis Ababa.
Methods: A comparative cross-sectional study was conducted from February, 2016 to
Jun 2017 on 79 patients attending the Oncology clinic at Tikur Anbessa Hospital.
Components of metabolic syndrome, including fasting serum glucose, serum triglyceride,
serum high density lipoprotein, blood pressure and waist circumference, was measured in
all of the patients. In addition, serum total cholesterol, serum low density lipoprotein was
measured with 5010 photometer , and information gathered on smoking and other
lifestyle practices, including diet and exercise.
Result: Of 79 patients, 29 had MS; 58.2% males; mean-age 48.6 years with range (26 to
78) and 41.8 % Female; mean age 44.6 years with range (20 to 78). Among the MS
group, 45.6 % had high blood pressure, 26.6 % had increased waist circumference, 67.1%
had serum blood glucose level greater than 100 mg/dL, 68.3 % had low high-density
lipoprotein cholesterol level< 50 mg/dl for female &< 40mg/dl for male , 57 % had
increased triglyceride level, and 3.8 % were obese [body mass index (BMI) >30 kg/m2].
In present study 29 % patients were presented 3 criteria of MS. From total colorectal
cancer patients 53.2 % had colon cancer, 46.8 % had rectal cancer and 12.7 % had stage
I,40.5 % had stage II (IIa,IIb & IIc), 25.3 % had stage III (a,b,c) and 21.5 % had stage IV
disease.
CONCLUSION: MS is positively associated with adenomas and colorectal cancer.
However, there is not enough information in Ethiopia to justify screening in patients with
MS. No previous study has evaluated this association in Ethiopian patients.
KEYWORDS: colon cancer, rectal cancer, metabolic syndrome, obesity
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Keywords
Colon cancer; Rectal cancer; Metabolic syndrome; Obesity