Survival Time to Death and its Predictors among Tuberculosis Patients Who Have Started Anti-TB Treatment in Selected Health Centers of Addis Ababa, Ethiopia: A Retrospective Cohort Study
| dc.contributor.advisor | Prof. Gedif, Teferi | |
| dc.contributor.advisor | Dr.Medhin, Girmay | |
| dc.contributor.author | Teketelew, Girma | |
| dc.date.accessioned | 2020-11-29T07:17:31Z | |
| dc.date.accessioned | 2023-11-06T08:09:57Z | |
| dc.date.available | 2020-11-29T07:17:31Z | |
| dc.date.available | 2023-11-06T08:09:57Z | |
| dc.date.issued | 2020-01 | |
| dc.description.abstract | Background: Tuberculosis remains the leading cause of morbidity and mortality globally and in Ethiopia despite different strategies have been designed and implemented to combat it. Survival time and its predictors among tuberculosis patients who enrolled to care in selected health centers in Addis Ababa were assessed. Method: A retrospective cohort study was conducted in 20 selected health centers of Addis Ababa city, Ethiopia. Data were collected from April 1 to August 30, 2018 by reviewing medical records of tuberculosis patients who were registered from May 2016 to May 2017. Statistical software STATA version 14 was used for analysis of the data. Kaplan–Meier curve and log-rank test was employed to investigate the statistical significance of the difference in survival experience among different categories of patients. Cox-proportional hazard and accelerated failure time model was used to assess the relationship between baseline variables and mortality. The strength of association was presented by hazard ratio with 95% CI and results were reported significant at P ≤ 0.05. Results: The medical records of 371 patients were included in the analysis of which 136 (36.7 %) died during the treatment period. Majority of TB deaths occurred within two months of the start of treatment and the overall estimated median survival time was 157 days. Based on akaikie information criterion, weibull accelerated failure time model manifested better results as compared with other models. In multivariable weibull model, age (HR=0.98, P=0.04), baseline weight (HR=0.96, P=0.03), tuberculosis treatment phase (continuation phase, HR=0.48, P≤0.01) and tuberculosis type (pulmonary negative TB, HR=19.92, P≤0.01) were found to be independent predictors of time to death of tuberculosis patients. Conclusions: Most of the patients died at the end of study period. This warrants that, special attention and follow up with nutritional support for pulmonary negative patients and underweight patients to reduce deaths and for better clinical and treatment outcome. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/23694 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Mortality, Predictors, Survival model, Survival time, Tuberculosis | en_US |
| dc.title | Survival Time to Death and its Predictors among Tuberculosis Patients Who Have Started Anti-TB Treatment in Selected Health Centers of Addis Ababa, Ethiopia: A Retrospective Cohort Study | en_US |
| dc.type | Thesis | en_US |