Pattern of Autoimmune Bullous Disorders Based on Histopathological Diagnosis, in ALERT Hospital, Addis Ababa, Ethiopia 2021: An Eight Years (2014-2021) Retrospective Study
| dc.contributor.advisor | Melaku, Aklilu (MD, Assistant Professor of Dermatopathology) | |
| dc.contributor.advisor | Ayele, Adane (MD, Assistant Professor of Dermatopathology) | |
| dc.contributor.advisor | Mulubirhan, Edom(MD, Assistant Professor of Dermatopathology) | |
| dc.contributor.author | Tadesse, Yohannes | |
| dc.date.accessioned | 2022-01-28T12:13:11Z | |
| dc.date.accessioned | 2025-01-08T14:33:34Z | |
| dc.date.available | 2022-01-28T12:13:11Z | |
| dc.date.available | 2025-01-08T14:33:34Z | |
| dc.date.issued | 2021-08 | |
| dc.description.abstract | Background: Autoimmune bullous diseases are a group of rare, acquired disorders causing blistering of the skin and/or mucous membranes characterized by overlapping features, resistance to treatment, and run a chronic course associated with significant morbidity and mortality. The incidence of autoimmune bullous diseases among the general population is reported as 14.5/million/year. Therapy of bullous diseases consists of suppressing the immune system, controlling inflammation and improving healing of erosions. Majority of autoimmune bullous diseases are chronic diseases that can cause physical and emotional distress which is exacerbated by the need to often have lifelong treatment with immunosuppressive therapies that have potentially severe adverse effects. To the knowledge of the investigator, there is no study conducted regarding the prevalence of auto immune bullous diseases in Ethiopia. Objective: Assess the pattern of autoimmune bullous diseases based on histopathological diagnosis in ALERT/AHRI hospital from 2014-2021 Methods: A retrospective cross sectional study was conducted at ALERT/AHRI. Histopathologic reports of all patients from January, 2014- June, 2021 were reviewed and cases with autoimmune conditions were selected. Obtained data were coded and entered using EpiData version 4.6.0.2, and it was cleaned and analyzed using SPSS. Descriptive analysis of basic participant’s characteristics and disease pattern of autoimmune disease was conducted. Result: From the 13,563 patients sent for biopsy analysis, 134 patients were sent for histopathology confirmatory test for AIBD in the study period, 86 study participants who full fill the operational definition were enrolled and analyzed. Among these 37.2% of them were male and the rest 62.8% were female, with a mean age of 40.9 year, the minimum age of disease onset being 7 month of age and the maximum age of disease onset was 82 years old. The most frequent AIBD was Bullous pemhigoid with 34.8% (n=30), followed by pemphigus foliaceous and pemphigus vulgaris each being 24.4% (n=21). Conclusion and recommendations: This study found bullous pemphigoid is the most prevalent in the assessed institution site. The overall mean age of the patients being 40.9 years, with a minimum age of 7 month and maximum of 82 years. Moreover, AIBD was seen in higher predominance in female patients, it is recommended for researchers to conduct a prospective study including other hospitals with a clinical correlation plus a qualitative study to assess how to improve the quality of life for such patients. Moreover, it is recommended to use a confirmatory diagnosis of AIBD i.e. immunofluorescence study for further researches. | en_US |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/29785 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Autoimmune bullous Disorders,Histopathological Diagnosis | en_US |
| dc.title | Pattern of Autoimmune Bullous Disorders Based on Histopathological Diagnosis, in ALERT Hospital, Addis Ababa, Ethiopia 2021: An Eight Years (2014-2021) Retrospective Study | en_US |
| dc.type | Thesis | en_US |