Measuring the Electrical Property and Infrared Light Sensitivity of Pre Ionized 24 Hour Treated Breast Cancer Cells Using Laser Trapping Techniques
| dc.contributor.advisor | Endries Muhammed (PhD) | |
| dc.contributor.author | Yetwale Alemu | |
| dc.date.accessioned | 2024-02-15T08:08:20Z | |
| dc.date.available | 2024-02-15T08:08:20Z | |
| dc.date.issued | 2023-09 | |
| dc.description.abstract | A study was conducted to introduce a novel method utilizing laser trapping techniques for measuring the electric charge and coefficient of the laser trap for breast cancer cells treated continuously for 24 hours. The 4T1 breast cancer cells used in this study were treated with a compound called 2-Dodecyl-6-methaxycyclohexa-2, 5-diene-1, 4-dione (DMDD). A high-power infrared laser operating at 1064nm was utilized to trap individual 4T1 cells from the group treated continuously for 24 hours. The measured values for the spring constant (k) ranged from 0.05 μN/m to 1.11 μN/m, with an average value of 0.38 μN/m. The data showed a high correlation, as indicated by an R-square value of 0.98. The charge developed on each of the 24-hourly treated breast cancer cells was quantified relative to the charge of an electron. On average, the cells exhibited a charge of -2249.55 ± 1983.89 units. It was observed that the charge developed on the cell surface was influenced by the size of the cells. As the cells moved closer to the laser trap, their charge increased, while their velocity, acceleration, and momentum decreased. After determining the electrostatic force and trapping force, a homogeneous second-order differential equation was solved to further analyze the system. This study provides valuable insights into the relationship between charge development, spring constant, and cell size in continuously treated breast cancer cells using laser trapping techniques. Velocity and acceleration decreases as the cells approaches to the trap and spring constant and mass have positive correlation to the charge developed on the cells | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/1787 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Measuring the Electrical Property | |
| dc.subject | Infrared Light Sensitivity | |
| dc.subject | Pre Ionized 24 Hour Treated | |
| dc.subject | Cancer Cells Using Laser | |
| dc.subject | Trapping Techniques | |
| dc.title | Measuring the Electrical Property and Infrared Light Sensitivity of Pre Ionized 24 Hour Treated Breast Cancer Cells Using Laser Trapping Techniques | |
| dc.type | Thesis |