Change in Serum Cardiac and Inflammatory Biomarkers Level Following Chemotherapy Treatment among Female Breast Cancer Patients Attending at Tikur Anbessa Specialized Hospital
| dc.contributor.advisor | Seifu Daniel | |
| dc.contributor.advisor | Mulugeta Yonas | |
| dc.contributor.author | Getie Muluabay | |
| dc.date.accessioned | 2020-03-23T11:58:02Z | |
| dc.date.accessioned | 2023-11-29T04:18:22Z | |
| dc.date.available | 2020-03-23T11:58:02Z | |
| dc.date.available | 2023-11-29T04:18:22Z | |
| dc.date.issued | 2019-08 | |
| dc.description.abstract | Chemotherapy is long been recognized that a well- established therapeutic approach for several malignancies including breast cancer. But the clinical efficacy of this drug is often limited by its related cardio toxicity. The assessment of multiple cardiac biomarkers can be used in identifying patients at increased risk and adverse outcomes from chemotherapy. This approach has significant importance to predict which patients will have adverse cardiac effects from chemotherapy as well as treat damage at an earlier stage, preserve patient health, and improve quality of life. Objective: The aim of the present study was to evaluate changes in cardiac and inflammatory biomarkers level following chemotherapy treatment among female breast cancer patients attending at Tikur Anbessa specialized hospital. Materials and methods: Hospital based retrospective study was conducted in 40 female breast cancer patients at TASH. Elecsys 2010 Troponin-T immunoassay analyzer ( to measure serum cTnT level ) , Roch/hitachi cobas c 502 analyzer ( to measure serum CKMB and CRP levels) ) wereand R and D systemic luminex performance assay( to measure serum IL-6 and TNF- used in 40 paired breast cancer patient samples retrieved from a repository specimen of an ongoing thematic research project. Data were analyzed using SPSS software version 23 package and a p value < 0.05 was considered statistically significant. Results: In the female breast cancer patients receiving chemotherapy treatment, the mean serum levels were significantly increased than their respective baselinecTnT, CKMB, CRP and TNF- values. No significance difference was found in the level of IL-6 between the base line and during chemotherapy treatment. 20%, 15%, 14% of the breast cancer patients had elevated cTnT, CK-MB and CRP levels after the three cycles of chemotherapy treatment respectively and 15% of patients had a baseline elevated levels of CRP compared with their respective cutoff value. Conclusion: Cardiac biomarkers are significantly increased up on chemotherapy treatment Key words: chemotherapy, cardio toxicity, cardiac biomarkers, inflammatory markers | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21222 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Chemotherapy, cardio toxicity, cardiac biomarkers, inflammatory markers | en_US |
| dc.title | Change in Serum Cardiac and Inflammatory Biomarkers Level Following Chemotherapy Treatment among Female Breast Cancer Patients Attending at Tikur Anbessa Specialized Hospital | en_US |
| dc.type | Thesis | en_US |