Evaluation of antidiarrheal activity of aqueous extract of the pulp and seeds of the fruit of Opuntia ficus-indica (cactaceae) in rats
| dc.contributor.advisor | Nedi, Teshome (PhD) | |
| dc.contributor.author | Boranto, Belachew | |
| dc.date.accessioned | 2018-12-30T18:16:54Z | |
| dc.date.accessioned | 2023-11-06T08:08:11Z | |
| dc.date.available | 2018-12-30T18:16:54Z | |
| dc.date.available | 2023-11-06T08:08:11Z | |
| dc.date.issued | 2018-11 | |
| dc.description.abstract | Evaluation of antidiarrheal activity of aqueous extract of the Pulp and Seeds of the fruit of Opuntia ficus-indica (Cactaceae) in Rats. Belachew Boranto Addis Ababa University, 2018 The fruits of Opuntia ficus-indica (L) Mill is one of medicinal plants claimed to have antidiarrheal potential, but with no scientific evidence. This study is aimed at investigating the antidiarrheal activity of aqueous extract of the pulp and seeds of the fruit of Opuntia ficus-indica in rats. The antidiarrheal activity was evaluated using castor oil induced diarrheal model, anti-enteropooling and charcoal meal test in rats of either sex. In this work, the test groups received a graded dose (100, 200 and 400 mg/kg) of aqueous extract of the pulp and seeds of the fruit of Opuntia ficusindica, whereas positive controls received either Loperamide (2.5 mg/kg) or Atropine (3 mg/kg) and negative controls received vehicle (10 ml/kg). Pretreatment of rats at the doses of 100, 200 and 400 mg/kg of the pulp and seed of Opuntia ficus-indica caused a significant reduction in the frequency of total number of stools and wet stooling as well as in delaying the onset of diarrhea as compared to the controls. Both extracts showed a dose-dependent inhibition (R2=0.908 for pulp and R2 =0.994 for seed) on the castor oil induced intestinal fluid accumulation. The extracts also showed significant (p<0.001) inhibition in intestinal motility in both normal and castor oil induced models. In conclusion, the results obtained in this study suggest that both pulp and seed extracts of the fruits of Opuntia ficus-inidca have beneficial effect in controlling diarrhea in experimental rats and this provides a support for the traditional use of the plant as an antidiarrheal remedy. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/15355 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Ababa Universty | en_US |
| dc.subject | Antidiarrheal activity, Castor oil induced diarrhea, Gastrointestinal transit, Antienteropooling, Opuntia ficus-inidca | en_US |
| dc.title | Evaluation of antidiarrheal activity of aqueous extract of the pulp and seeds of the fruit of Opuntia ficus-indica (cactaceae) in rats | en_US |
| dc.type | Thesis | en_US |