Cross sectional comparative study of hematological parameters in people withatherosclerotic cardiovascular disease and those with cardivascular risk alone.
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Date
2021-06
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Addis Abeba University
Abstract
Background
Cardiovascular disease (CVD) is the foremost killing disease worldwide and ASCVD is one
of the prominent types of CVD which is mainly associated with a condition called
atherosclerosis. Various risk factors are associated with its incidence. These are
hypertension, diabetes, dyslipidaemia, smoking, genetic factors etc. Presence of ASCVD as
well as its risk factors results in disturbance of various physiological and biological function
of the body. Haematological parameters for instance tend to be disturbed in the presence of
abnormal physiological and biological function.
Aim: Therefore, in this prospective cross sectional comparative study we have assessed and
compared the pattern of haematological parameters in peoples having established
atherosclerotic cardiovascular disease (ASVD) vs. peoples having ASCVD risks alone who
attended TASH Addis Ababa, Ethiopia and also correlated haematological parameters with
the novel inflammatory marker hsCRP.
Method: -Blood samples were collected from study participants and serum was extracted
for the lipid and hsCRP analysis and the remaining whole blood is used for haematological
parameters determination using SYSMEX machine while Roche/Hitachi Cobas 6000
analyser that uses immunoturbidimetric assay was used to determine hsCRP whereas lipid
profile was first determined by spectrophotometric analysis and then repeated by using
Roche/Hitachi Cobas 6000 analyser.
The total number of participant was100 (50 in each group).
Result: -White blood cells (WBC), mean cell volume (MCV), red cell distribution width
(RDW) and monocyte (MONO) are significantly higher in pre-existing ASCVD and also
have significant association with the presence of ASCVD. Mean platelet volume (MPV)
significantly higher in ASCVD risked group and associated with the presence of the risk.
Additionally, in correlation analysis of highly sensitive C-reactive protein (hsCRP) with
hematological parameter hsCRPs show significant correlation with MPV. It is higher and
significantly associated with the presence of risk factors as well.
Conclusion: -Using this affordable, routinely tested and easily available tests may help to
infer future ASCVD risk as well as the presence of ASCVD morbidity while hsCRP level in
comparison group vs. cases require further study.
Description
Keywords
Cardiovascular disease,Atherosclerosis,Haematological parameters