Adoptive Transferor Lymphocytes And Its Role In Protecton Against Schist soma Manzoni Infection In Arvcicanthus Sp Rats
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Date
1982-07
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Addis Ababa University
Abstract
adoptive transfer of protection from inducted donor
acanthus !!l? rats to uninstructed recipients was attempted
by va~yj.ng some parameters such as the inf8ction period of
donor rats and the time of transfer relative to challenge.
Concurrent investigation on the effect of.': 11ctorologous
infection and fractionation of cells "idS also carried out.
It ",as found that cells from 2 month .. ;.nf8ctcd donors had
high ability to transfer resistance to recipient rats )
while cells f"om 1. 75 and 3 month-infected donors shO\.,ed
partial abi Ii ty and those from 2.5 mont11",infected donors
sho"led an unexpected inhibitory effect on transfer
recipients. Transfers done close to challengu day confer
almost complete immunity to recipient rCl"ts, \,:,.~, ..
'"
Heterologous cestode infection in these rc:ts appear to
playa secondary role in protecting against Eo !~ansoni
infections, ,.,hile it ",as also found that unfrilctionated cells
have more ability to transfer resistance thul1 fractionated
cells.
Possible immunological mechanisms involvGd during these
events ~nd the practical significance of the work are
briefly discussed.
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Biology