Prevalence and Predictors of Drug Related Hospitalizations in Multicenter Study Settings, Addis Ababa, Ethiopia: A Prospective Observational Study

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Addis Abeba University


Abstract Background: Drug related hospitalizations (DRHs) represent a substantial burden on health care resources worldwide and are considered as one of the leading causes of morbidity. Studies carried out in various countries, the extent of DRHs has been estimated to be between 16% to 41.3%.Of those, more than half of the cases were preventable. Whereas in Ethiopia the prevalence and factors independently associated with DRHs are not known. Therefore, the aim of this study was to determine the prevalence and predictors of DRHs in emergency ward of Tikur Anbessa Specialized Hospital, Zewditu Memorial Hospital and Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia. Methods: A prospective observational study was conducted from August to September, 2020 in the three selected hospitals. Participants were interviewed and their medical charts were reviewed through a structured data collection format. DRHs were assessed using Helper’s and strand’s drug therapy problems classification system. The data were entered and analyzed using Statistical Package for Social Science (SPSS) version 26.Descriptive statistics and binary logistic regressions were performed. P-value <0.05 in multiple binary logistic regression was taken as significant level and results were presented in texts, tables and charts. Result: The numbers of recruited and screened patients were 2655.Out of them, 423 participants who fulfilled the inclusion criteria were enrolled in the study. Of those who met the inclusion criteria, more than half of them (216, 51.1%) were females. The mean age (SD) of the study participants was 47.50 (±17.21) years. The mean length of hospital stay (SD) was 10.29(±8.99) days and ranges from 2 to 96 days. Among the included study participants, near to three fifth (245, 57.9%) of patients were hospitalized due to drug related problems, of which 87.8% were deemed preventable. Of those, more than half (130, 53%) of them experienced failure to receive drugs followed by untreated indications (94, 37.8%). The main reasons for failure to receive drugs were due to patients preferred not to take the medications (43, 33.1%), they feared adverse events (18, 13.8%) ,drug products were not available (17, 13.1%), patients felt better (17,13.1%) and cost of medications was too expensive (16,12.3%).Factors associated with DRHs were old age (age > 64 years (Adjusted Odds Ratio [AOR] = 7.451, 95%CI: 1.889-29.397), tertiary educational level (AOR=0.360, 95%CI: 0.141-0.923), participants who did not have any occupation (AOR=3.409, 95%CI: 1.120-10.374),students (AOR=6.331,95%CI:1.375-29.153) presence of co-morbid diseases (AOR=2.004,95%CI: 1.095-3.668), and hospital stay > seven days (AOR=2.186, 95%CI: 1.412-3.382). Conclusion: DRHs were common among emergency ward patients in the study settings. More than four fifth of DRHs were deemed to be preventable.



Drugs related problems, Drug related hospitalization, Predictors, Prevalence, Ethiopia.