System and Site Readiness for Conducting Active Surveillance of Adverse Events Following Immunization in Addis Ababa, Ethiopia.
| dc.contributor.advisor | Makonnen Eyasu | |
| dc.contributor.advisor | Yimer Getnet | |
| dc.contributor.author | Dagnachew Eden | |
| dc.date.accessioned | 2021-10-31T07:19:37Z | |
| dc.date.accessioned | 2023-11-06T08:10:36Z | |
| dc.date.available | 2021-10-31T07:19:37Z | |
| dc.date.available | 2023-11-06T08:10:36Z | |
| dc.date.issued | 2021-06 | |
| dc.description.abstract | Background: Vaccine pharmacovigilance (PV) aims to detect, assess, comprehend, communicateand manage adverse events followingimmunization (AEFI). To help distinguish vaccine relatedAEFIs from coincidental occurrences, an active PV prospective surveillance programs (e.g. hospitalbasedsentinel sites) are needed. We describe our experience in assessing system and facilityreadiness for implementing a pilot active AEFI PV in Addis Ababa, Ethiopia. Method: Three hospitals were selected for this study after objectively evaluating all the governmenthospitals in Addis Ababa using parameters ;ongoing collaborations with the Ethiopian Food andDrug Authority (EFDA), previous experience in research, being referral government hospital andproximity to key AEFI stakeholders in Addis Ababa. We developed a readiness assessment togetherwith scoring tool and system readiness assessment tool by adapting published framework. The siteassessment was conducted via in person interview of specific departments in each hospital while adesk review of AEFI guideline, Expanded Program for Immunization (EPI) guideline, EFDA andEthiopian Public Health Institute (EPHI) website was done for system readiness. Results: Three out of thirteen (23.1%) hospitals in Addis Ababa met the criteria for our siteassessment. During the system readiness assessment, we found that essential components were inplace, Specific regulation and proclamation on AEFI surveillance except mentioning responsibilityof every stakeholder on the guideline was, however absent. Based on the scoring tool, Tikur AnbessaSpecialized Hospital (TASH) scored 94 out of 155 (60.6%), Saint Paul Hospital Millennium MedicalCollege scored 75 out of 155 (48.38%) and Gandi Memorial Hospital scored 62 out of 155 (40%).Paper-based records were used by all departments except those of laboratory and radiology in TASHand SPHMMC. International Classification of Disease (ICD) 9/10 coding was only used in TASH.Copies of national AEFI guidelines were not present in all departments and reporting forms werefound only in 4 departments surveyed across the three hospitals. Staff at both Gandi MemorialHospital and SPHMMC reported absence of training on AEFI surveillance. Conclusion: TASH has the highest score after assessing readiness for piloting active AEFIsurveillance. We also identified the following areas for improvement in all hospitals to ensuresuccessful implementation: training, making guideline and reporting forms available, and ensuring asystem that accommodates paper-based and electronic record systems. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28429 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Immunization,System | en_US |
| dc.title | System and Site Readiness for Conducting Active Surveillance of Adverse Events Following Immunization in Addis Ababa, Ethiopia. | en_US |
| dc.type | Thesis | en_US |