Fluctuation-Driven Transport of Molecules in an Asymmetric Membrane Channel

No Thumbnail Available



Journal Title

Journal ISSN

Volume Title


Addis Ababa University


Aquaglyceroporin GlpF selectively conducts water and linear polyalcohol, such as glycerol across the inner membrane of Escherichia coli, with absolute exclusion of ions and charged solutes and without dissipation of the electrochemical potential across the cell membrane. There is a current interest in the study of the transport of glycerol inside the G1pF specially after the structure of the PMF of GlpF is determined by SMD simulations. Using this structure, Schulten and Kosztin [7J have numerically studied the behavior of the current density by considering various cases of external tilting force. Being interested in seeking analytical results, we model the potential of G1pF by a ratchet potential and obtain analytical expression for the current density of glycerol through GlpF for various cases of interest. In addition we compare our results with the numerical results obtained in [7J and identify regions where the analytical and numerical results agree



Asymmetric Membrane Channel