Fluctuation-Driven Transport of Molecules in an Asymmetric Membrane Channel
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Date
2005-06
Authors
Dinkayehu, Alemayehu
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Publisher
Addis Ababa University
Abstract
Aquaglyceroporin GlpF selectively conducts water and linear polyalcohol, such as
glycerol across the inner membrane of Escherichia coli, with absolute exclusion of
ions and charged solutes and without dissipation of the electrochemical potential
across the cell membrane. There is a current interest in the study of the transport
of glycerol inside the G1pF specially after the structure of the PMF of GlpF is determined
by SMD simulations. Using this structure, Schulten and Kosztin [7J have
numerically studied the behavior of the current density by considering various cases
of external tilting force. Being interested in seeking analytical results, we model the
potential of G1pF by a ratchet potential and obtain analytical expression for the current
density of glycerol through GlpF for various cases of interest. In addition we
compare our results with the numerical results obtained in [7J and identify regions
where the analytical and numerical results agree
Description
Keywords
Asymmetric Membrane Channel