Cyxochalasins from the Fungus Xylaria
| dc.contributor.advisor | Dagne Ermias (PhD) | |
| dc.contributor.author | Mitiku Solomon | |
| dc.date.accessioned | 2018-06-25T08:29:33Z | |
| dc.date.accessioned | 2023-11-09T16:17:54Z | |
| dc.date.available | 2018-06-25T08:29:33Z | |
| dc.date.available | 2023-11-09T16:17:54Z | |
| dc.date.issued | 1994-06 | |
| dc.description.abstract | Three cytotoxic cytochalasins were isolated and characterized from Xylaria sp. (LEP-12) cultured on a sterile moist rice. The fungus grown on the above medium for 14 days at room temperature produced three cytochalasins, identified by spectroscopic methods and chemical derivatizations as cytochalasin Q (3), 19,20-epoxycytochalasin Q (4) and 19,20-epoxydeacetylcytochalasin Q (5). However only compounds 3 and 4 could be isolated when the fungus was allowed to grow in the medium for 18 days. This is the first report of cytochalasin Q from the genus Xylaria. All three cytochalasins were lethal to brine shrimp with LCJO value of 5, 5 and 2 /xg/ml for compounds 3, 4 and 5, respectively | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/12345678/3074 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa Universty | en_US |
| dc.subject | Cyxochalasins | en_US |
| dc.title | Cyxochalasins from the Fungus Xylaria | en_US |
| dc.type | Thesis | en_US |