Methods for Quantitative Extraction of Niclosamide Based on Supported Liquid Membrane and High Performance Liquid Chromatographic Determination
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Date
2006-07
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Addis Ababa Universty
Abstract
From literature review it is possible to hypothesize that a method for the preconcentration
and isolation of niclosamide from indigenous plant materials using supported liquid
membrane (SLM) can be developed. Neutral molecules of niclosamide can be extracted
from a flowing aqueous solution to a stagnant basic acceptor solution across a liquid
membrane. The efficiency of the extraction process depends on the pH values of donor
and acceptor solutions, the flow rate and the carry-over (COE) effects when ordinary
SLM configuration is applied. Therefore the optimization of these factors was also
suggested. Comparison of simple transport and carrier-mediated mechanisms can be
made; it is suggested that simple transport mechanism would be more effective. The use
of hollow fiber supported liquid membrane (HFSLM) mode of extraction is also
suggested for comparison purpose. The applicability of the method of extraction should
be investigated by spiking analyte sample solutions to the real sample. After developing
and optimizing the method, application to the extraction and determination of
niclosamide from Hagenia abyssinica (koso), Glinus lotoides L. (meterre), Embelia
schimperi vatue (enqoqo), and Cucurbita pepo L. (dubba) was suggested
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Membrane and High Performance Liquid