Reactions and Structural Studies of Cu(II) and Fe(III) Ions with Clofentezine Derivative of Hydrazine
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Date
2001-07
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Addis Ababa Universty
Abstract
3,6-Bis(2-hydrazinophenyl)-1,2,4,5-tetrazine has been derivatized from the reaction of
3,6-bis (2-chlorophenyl)-1,2,4,5-tetrazine with hydrazine hydrate. Characterization was
made using UV-Vis, IR, IH NMR, and BC NMR spectroscopy. Attempts to prepare
metal complexes between metal ions such as Cu(II), Pe(III), Cr(III) and Ni(II) with the
ligand, BHPT, were observed to be the decomposition of BHPT to 3,6-bis (2-
chlorophenyl)-1,2,4,5-tetrazine. UV-Vis, IR, IH NMR, 13C NMR, AAS, conductivity
measurement and analytical data have been used to characterize BHPT and 3,6-bis (2-
chlorophenyl)-1,2,4,5-tetrazine.
The kinetic study of the decomposition of BHPT to 3,6-bis (2-chlorophenyl)-1,2,4,5-
tetrazine, enhanced by the metal chlorides, revealed that the reaction is a second order
with rate constant of 94.7 morlLsec·1 at 4°C in acetonitrile solution. This reaction was
also tested at pH = 4 (rate constant = 28.06 morILsec·l) and pH = 9.2 (rate constant =
13.7 morILsec·l) at 50°C. Prom the kinetic data plausible mechanism is proposed.
Antimicrobial test was conducted for the ligand on Escherichia coli, Proteus and
Staphilococcus aureus. The ligand has no inhibition effect on the growth of the above
bacteria
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Keywords
Cu(II) and Fe(III) Ions