A systematic Review and Meta-analysis of Antimicrobial Prescriptions in East Africa
| dc.contributor.advisor | Medhin Girmay | |
| dc.contributor.advisor | Makonnen Eyasu | |
| dc.contributor.advisor | Otiku Paul | |
| dc.contributor.author | Joan Acam | |
| dc.date.accessioned | 2021-11-09T12:01:42Z | |
| dc.date.accessioned | 2023-11-06T08:10:36Z | |
| dc.date.available | 2021-11-09T12:01:42Z | |
| dc.date.available | 2023-11-06T08:10:36Z | |
| dc.date.issued | 2021-06 | |
| dc.description.abstract | Background: Antimicrobial resistance is one of the major global health problems that has beenworsened due to poor antibiotic stewardship by health workers and improper use ofantimicrobial by the patients among other factors. Quality data representative of the extent ofpoor antimicrobial stewardship in low- and middle-income countries is scanty, but highincidences of antimicrobial resistance are increasingly reported in many settings across theglobe. The objective of the present study was, therefore, to evaluate prescriptions forantimicrobials in East Africa. Methods: A comprehensive literature search strategy that includes text words and medicalsubject headings was developed and applied to predefined electronic databases. Tworesearchers independently screened the titles and abstracts of the outputs of the literaturesearch. Full texts were then independently reviewed by the two researchers. Extracted datafrom included studies were pooled using meta-analysis. Results: Majority of the included studies (30.8%) were retrieved from Ethiopia, followed bySudan, Kenya and Tanzania each contributing 19.2%. The overall proportion of encounter withantimicrobials reported was 57% (95%CI 42%; 73%). Ethiopia had an overall patient encounterwith antimicrobials of 63% [95%CI: 50%, 76%] followed by Sudan with an overall encounterwith antimicrobials of 62% [95%CI: 34%, 85%]. Studies included from Kenya reported theoverall encounter with antimicrobials of 54% [95%CI: 15%, 90%], whereas studies fromTanzania reported an overall patient encounter with antimicrobials of 40% [95%CI: 21%,60%]. Conclusion: Prescription patterns demonstrated in this review significantly deviate from WHOrecommendations suggesting inappropriate antimicrobial use in the East African countries.Considering the global threat posed by antimicrobial resistance, perhaps countries with fewresearch being carried out on antimicrobial use patterns and resistance should focus moreresources on this important research agenda as a matter of public health priority. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28581 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Antimicrobial Prescriptions | en_US |
| dc.title | A systematic Review and Meta-analysis of Antimicrobial Prescriptions in East Africa | en_US |
| dc.type | Thesis | en_US |