Adoptive Transfer of Lymphocytes and its Role in Protection against Schitosoma Mansoni Infection in Arvicanthus Species
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Date
1982-07
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Addis Ababa,University
Abstract
Adoptive transfe r o f pr o t f!c tio n f rom i nf 'ctcd don or
J.rvicanthus !.E. rats t o uninfec t ed r c cl pient~ was t!l ttt!mpted
by va ~ y ing s omc pilram ~~b.! rs such a s the i ntl:ction pe riod o f
donor r ats a nd the tine of tra ns f L; r r e l ati ve to c ha l ll.;nge .
Concurre nt inve stigation o n t he e ffect of h~'~ r o l o g ous
infec tion and fra ctio na tion o f c e ll s 11(l!:; ~lso carri(:d out.
It wa s f ound tha t cPlls from 2 mo n th- lnfLctcd dono rs had
high ability t o tra n s f c r r e sista ncl.! to rc:d,p i €..nt r ats
while c el ls f r om 10 75 a nd 3 month- infL:ctcc' Jonor s s howed
pa rtial a bi l ity and tho s e fr om 2 . 5 mo nth- infl:ctcd donors
showed an une xpe cted inhi b i t ory e f fect on t ransfe r
r e cipi e nts. Transfe rs d o ne c l o s e t o ch a ll L:ng~ nay c onfe r
almo s t c omple t e i mmunity t o r e cipie nt rats , \0,:.':"_
Heterologous c e stode infe ction in t hes(! r-~ts appt:"!<'Ir t o
play t!I s econdary r o l e in pro t ecting aguinst ,5 •• mansoni
infe ctions, while it wa s a l so f ound t hat u nfr~Ltio n a t ed cells
have mo r e ability t o tr n ~sf e r r c sis t~ n cc than fr actio na t ed
ce lls .
Po s s ible i~mun o l o gic a l me cha nisms involved dur i ng t hese
e ve nts and the pr actica l s ignifica nce of thL: Hark arc
briefly discuss ed .
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Keywords
Adoptive Transf'er of' Lymphocytes and Its Role In Protection Against SchisTosoma Mansoni Infection