Assessment of Serum lipid profiles and high sensititvity C-reactive protein among patients suffering from rheumatoid arthritis at Tikur Anbessa specialized Hospital, Addis Ababa, Ethiopia
No Thumbnail Available
Date
2018-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa Universty
Abstract
Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by severe pain of joints and swelling, joint damage and disability which leads to joint destruction and loss of function with unknown etiology. According to global burden of 2010 study, prevalence of 0.24%, rheumatoid arthritis is ranked among the top 15 of diseases causing disability worldwide. The complication of RA is related to cardiovascular diseases. The morbidity and mortality is related to systemic inflammation and dyslipidaemia.
Objective: The general objective of this project is to assess serum lipid profiles and high sensitivity C-reactive proteins among patients suffering from rheumatoid arthritis and attending in Tikur Anbessa Specialized Hospital ( TASH ), Addis Ababa, Ethiopia.
Material and Methods: Hospital based cross sectional comparative study was conducted to assess serum lipid profiles and high sensitivity C-reactive protein on rheumatoid arthritis patients in RA clinic at TASH. Patients who came to TASH during the study period were selected by convenience sampling method until the required sample size was achieved. Data was cleaned manually, coded, entered and analyzed by SPSS version 20. Written consent was obtained for willingness of patients to participate after getting official permission letter from Addis Ababa University and then from respective selected rheumatoid arthritis clinic.
Result: The result of this study demonstrated that there was significant elevation of mean ± SD of TC, TC/HDL, LDL/HDL and lowered value of HDL-C was seen among RA patients than controls (P-value < 0.05). The mean ± SD of inflammatory marker, hsCRP was significantly higher among rheumatoid arthritis patients compared to controls (P value <0.05). HDL-C had significant negative correlation with high sensitive C-reactive protein where as TC/HDL-C and LDL/HDL-C had significant positive correlation with hsCRP (P < 0.05).
Conclusion: In this study rheumatoid arthritis patients had lipid abnormalities and elevated systemic inflammation than controls. An increase in hsCRP and dyslipidaemia status among rheumatoid arthritis patients indicates the possible development of atherosclerotic event which is the underlying cause of cardiovascular risk. So, it is possible to conclude that RA patients are more likely to develop future cardiovascular coronary artery diseases compared to controls.
Description
Keywords
Rheumatoid arthritis, serum lipid profiles, cardiovascular risk, high sensitivity C-reactive protein