Electrochemical Determination of Folic Acid at Polybromocresol Purple Modifed Glassy Carbon Elelctrode

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Addis Ababa University


Polybromocresolpurple (PBCP) was used for the modification of glassy carbon electrode (GCE) to determine the electrochemical behavior of folic acid (FA) in 0.1 M PBS at pH 7.0 at the scan rate of 100 mV/s. The modified electrode was characterized and used to electrochemically determine FA using cyclic and differential pulse voltammetry. The oxidation peak current of FA at the modified electrode increased compared to the bare GCE, hence indicating that the BCP displays a significant improvement on the electrochemical oxidation of FA. The oxidation peak current of FA is proportional to its concentrations in the range of 20-100 μM with 0.987 correlation coefficient. The detection limit was found to be 1.772 μM. Based on the relationship between the oxidation peak current and square root of scan rate, the overall electrode process was found to be diffusion controlled at BCP/GCE. The modified electrode exhibited good sensitivity, and reproducibility for the determination of FA, indicating the capable applications of the modified electrode in real sample analysis.



Folic Acid, Modified Electrode, Polybromocresolpurple (Bcp), Electropolymerization, Cyclic Voltammetry, Differential Pulse Voltammetry