Fecal Carriage of Extended-Spectrum Beta-lactamase and Carbapenemase-Producing Enterobacteriaceae Among Hospitalized Patients at Debre Berhan Comprehensive Specialized Hospital, North Shoa, Amhara Regional State, Ethiopia.
| dc.contributor.advisor | Yimtubezinash Woldeamanuel | |
| dc.contributor.advisor | Daniel Asrat | |
| dc.contributor.author | Shenkute Demissew | |
| dc.date.accessioned | 2021-10-19T12:04:04Z | |
| dc.date.accessioned | 2023-11-05T09:35:48Z | |
| dc.date.available | 2021-10-19T12:04:04Z | |
| dc.date.available | 2023-11-05T09:35:48Z | |
| dc.date.issued | 2021-06 | |
| dc.description.abstract | Background: The control of methicillin resistant Staphylococcus aureus (MRSA) has become challenging, particularly in immunosuppressed individuals such as HIV-infected patients. Although a global health concern, the data regarding the prevalence and antibiotic resistance pattern of MRSA colonization among HIV- infected and HIV-negative groups is scarce in Ethiopia. Objective:The main objective of this study was to investigatethe prevalence of nasal carriage and antimicrobial susceptibility pattern of MRSA among adult HIV-infected and HIV-uninfected individuals at Adama Hospital Medical College, Adama, Ethiopia. Methods: The study was hospital-based case-control and involved 140 HIV-infected individuals and an equal number of sex- and age group- matched apparently healthy HIV-negative individualsfrom December, 2020 to March, 2021. Data related to demographic, household and clinical features was collected using a structured questionnaire and nasal swab samples were collected by sterile cotton swab. S. aureusisolates were confirmed by colony characteristics and biochemical tests while MRSA was detected using Cefoxitin (30μg) discs by Modified KirbyBauer disk diffusion method. The data wereanalyzed using SPSS Version-25 and the values were considered to be significant if p<0.05 was obtained. Results: The prevalence of nasal carriage of S. aureus and MRSA strains were 34/140(24.3%) and 15/140(10.7%) respectively among the HIV-infected individuals, and the corresponding values within the control group were 19/140(13.6%) and 5/140(3.6%). In both study groups, the MRSA isolates were resistant to penicillin. The proportion of MRSA isolates that were multi-drug resistant were 7/15(46.7%) and 1/5(20%) in HIV-infected patients and HIV-uninfected groups. Conclusion: This study showed a high prevalence of S. aureus and MRSA nasal carriage rates in HIV-infected patients than in HIV-uninfected groups. Special attention should thus be given to the control of MRSA in people living with HIV/AIDS. In addition, regular surveillance and monitoring should be conducted to effectively control this ‗super bug‘ infections in high-risk groups like HIV-infected patients. -PE. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28256 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Fecal carriage, ESBL, carbapenemase, Enterobacteriaceae, Debre Berhan, Ethiopia, hospitalized patients | en_US |
| dc.title | Fecal Carriage of Extended-Spectrum Beta-lactamase and Carbapenemase-Producing Enterobacteriaceae Among Hospitalized Patients at Debre Berhan Comprehensive Specialized Hospital, North Shoa, Amhara Regional State, Ethiopia. | en_US |
| dc.type | Thesis | en_US |