Effect preeclampsia/Eclampsia on incidence rate of small for gestational age among pregnanat women in mekelle general Hospital and ayder comprehensive specialized hospital, Tigray, Northern Ethiopia.
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Date
2019-10
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Addis Abeba University
Abstract
Background: In low and middle-income countries including Ethiopia, small for gestational age is a serious health problem, due to an increase in fetal and neonatal mortality and morbidity. In Ethiopia and particularly in Tigray there is a paucity of information on incidence rate and predictors of small for gestational age among pregnant women.Therefore the aim of this study is to determine the effect of preeclampsia on the incidence of small for gestational age among pregnant women in Mekelle General Hospital and Ayder
Comprehensive Specialized Hospital, Tigray, Northern Ethiopia, 2019.
Methods: A retrospective cohort study was employed to compare the small for gestational age between the exposed; preeclampsia (n=239) and non exposed; normotensive (n=476) women who were antenatal care follow-up in Mekelle General Hospital and Ayder Comprehensive Specialized Hospital from January 01, 2014 to March 31,2019. Systematic sampling was used to select the study participants. A pre-tested structured data abstraction
checklist was used to extract data. Collected data were entered and cleaned using Epi Data version 3.1 and exported to STATA version 14 for analysis. The incidence rate was calculated dividing all small for gestational age cases in the cohort for the person-weeks of follow-up. The data analysis was performed by Cox proportional hazard model.
Results: The incidence rate of small for gestational age was higher among preeclampsia than normotensive women (94.5 versus 24.9 per 1000 person weeks, Z=9.42, p<0.000001).The hazard of small for gestational age was four times higher in preeclampsia women than normotensive pregnant women, (AHR=3.92, 95% CI 2.55-6.01), history of low birth weight (AHR=0.41, 95%CI 0.17-0.94), poor gestational weight gain (AHR=1.89, 95% CI 1.15-3.1) were significant predictors.
Conclusion and recommendation: There is a significant difference between preeclampsia and normotensive pregnant women in terms of the incidence rate of small for gestational age. Preeclampsia, a history of low birth weight and weight gain had significant predictors for small for gestational age. It is needed to strengthen the screening of preeclampsia for optimal fetal growth, and counseling on nutrients for adequate gestational weight gain. Further study will be also important to confirm the predictors at the community level.
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Small for gestational age, preeclampsia/eclampsia, Tigray