Cytopathologic Review of Breast Lesions and Correlation with Histopathologic Results at Tikur Anbessa Specialized Hospital: A Six Years and Eight Months Retrospective Study from 2015 - 2021.
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Date
2021-11
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Addis Ababa University
Abstract
Background: A palpable breast lump is always a cause of concern to the patient. Hence, accurate pathological diagnosis is crucial for further management and to evaluate the outcome. Clinical examination, imaging and FNAB are implemented in the assessment of breast lesions in the Triple Test. In this regard the role of FNAB is vital in the diagnoses of breast lesions particularly in identifying malignant lesions.
Objectives: The aim of this study was to determine cytopathologic patterns of breast lesions in TASH and to correlate Fine Needle Aspiration Biopsy results with the corresponding histopathologic results as to determine the validity of FNAB.
Methods: A retrospective descriptive cross-sectional study of 1327 patients who underwent FNAB of whom 145 had histopathology results over six years and eight months between January 2015 and August 2021 in TASH. Descriptive statistics of the cytology reports as well as diagnostic performance analysis of malignant and benign FNAB categories made using SPSS version 23.
Results: A total number of 1327 patients were included out of which 1214 (91.5%) were females and 113 (8.5%) were males. According to the IAC Yokohama system the malignant and benign categories of FNAB account 44% each of the total cases and the rest contributed by the suspicious, atypical and insufficient categories. Most of the Malignancies present in the 4 th and 5 th decades of life whereas benign cases happened a decade earlier. 145 of the cases were followed by histopathology. FNAB of benign and malignant lesions showed 96.0% accuracy, 96.3% sensitivity and 97.7% specificity.
Conclusion: The burden of malignancy in this setup (TASH) is high yet, FNAB remains to be a reliable and acceptable method for the diagnosis of breast lesions.
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Keywords
Pathological diagnosis, Breast lesions