The Antidiabetic Effects and Antioxidant Activities of Taverneira Abbysinicas’ Root Crude Methanol Extracts in STZ Induced Type 2 Diabetic Rats

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Addis Ababa University


Diabetes mellitus (DM) is a heterogeneous complex metabolic disorder resulting from defective insulin secretion, resistance to insulin action or both. Broadly it is classified into two categories type-1, and type-2. It is a chronic disease characterized largely by disordered metabolism, glucose urea, negative nitrogen balance, and hyperglycemia. In the long term hyperglycemia has pathologic effects such as atherosclerosis, neuropathy, nephropathy, and others which largely are due to oxidative stress. Since the currently available oral hypoglycemic drugs and insulin have limitations the search for better treatments is going on. Despite the developments of modern treatments the interests in the plant remedies have been renewed. In similar fashion to other countries, in the indigenous system of Ethiopian traditional medicine different plants are used to treat various diseases, such as diabetes mellitus, hypertension, malaria and gastrointestinal disorders of various origins of which Moringa stenopetala, Melia azedarach and Taverniera abyssinica are the most common. The present study was carried out to investigate the hypoglycemic and antidiabetic effects and antioxidant activities of the methanolic crude root extracts of Taverniera abyssinica in STZ induced diabetic rats. The effects of the plants’ crude root extracts on blood sugar, the level of plasma MDA, plasma total peroxides, plasma total antioxidant capacity was measured and the level of oxidative stress index was determined. Results of intraperitoneal glucose tolerance test showed that crude root extracts of Tavererneira abbysinica have hypoglycemic effect but not immediate. In the long term treatment the plants’ crude root extract exhibited anti-diabetic effects on day 10 (p<0.001), day 15 (p<0.001), and day 20 (p<0.001) at doses of 100mg/Kg and 200 mg/Kg per BW following intraperitoneal administration and was dose dependent with maximum effect observed at a dose of 200mg/Kg. The level of MDA was decreased by 74.07% in Taverniera abyssinica treated groups compared to diabetic control receiving 1.0mL of distilled water. . The present study also showed that the level TPP was decreased by 55.12% in Taverniera abyssinica treated group compared to diabetic control. But the level of TAC was higher by 5.43% in Taverniera abyssinica treated group compared to diabetic control. However, the level of TAC was increased the study showed the level of oxidative stress is decreased by half (50%) in Taverniera abyssinica treated groups compared to diabetic control. Generally, this study demeonstrated that the crude root extracts of Taverniera abyssinica has hypoglycemic, and antidibetic effects and antioxidant activities.



Diabetes mellitus, hypoglycemic effect, anti diabetic effect, antioxidant activities, methanolic crude root extracts, Taverniera abyssinica, intraperitoneal administration.